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FLASH GENE
Symbol IGFBP7 contributors: mct - updated : 17-01-2018
HGNC name insulin-like growth factor binding protein 7
HGNC id 5476
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       loss of function
in renal clear cell carcinoma with poor prognosis
tumoral     --over  
in prostatic cancer
tumoral     --low  
is a critical step in melanoma genesis
tumoral     --low  
  • loss of expression has a functional role in thyroid carcinogenesis (Vizioli 2010)
  • Susceptibility to autism spectrum disorder
    Variant & Polymorphism other
  • functional variant -418G>C in the IGFBP7 promoter is associated with reduced risk of squamous cell carcinoma of head and neck, likely by enhancing the IGFBP7 promoter and DNA-protein binding activities (Huang 2010)
  • Candidate gene
    Marker
  • MYH7, IGFBP7, ANXA2, and DES are all excellent candidate plasma biomarkers of heart failure
  • Therapy target
  • anticancer agent for treatment of metastatic melanoma and other cancers (Wajapeyee 2009)
  • ANIMAL & CELL MODELS