Symbol
| IGFBP7
| contributors: mct - updated : 17-01-2018
|
HGNC name
| insulin-like growth factor binding protein 7
|
HGNC id
| 5476
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
|  
| loss of function
|
in renal clear cell carcinoma with poor prognosis | tumoral
|  
|  
| --over
|  
|
in prostatic cancer | tumoral
|  
|  
| --low
|  
|
is a critical step in melanoma genesis | tumoral
|  
|  
| --low
|  
|
loss of expression has a functional role in thyroid carcinogenesis (Vizioli 2010) | |
Susceptibility
|
to autism spectrum disorder |
Variant & Polymorphism
other
| functional variant -418G>C in the IGFBP7 promoter is associated with reduced risk of squamous cell carcinoma of head and neck, likely by enhancing the IGFBP7 promoter and DNA-protein binding activities (Huang 2010) |
|
|
Candidate gene
Marker
| MYH7, IGFBP7, ANXA2, and DES are all excellent candidate plasma biomarkers of heart failure | Therapy target
| anticancer agent for treatment of metastatic melanoma and other cancers (Wajapeyee 2009) |
| |