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FLASH GENE

Symbol

IGFBP7

contributors: mct - updated : 17-01-2018

HGNC name	insulin-like growth factor binding protein 7
HGNC id	5476

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001553 5 - 1124 NP_001544 29 282 - Oh (1996)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly   stomach       highly Endocrine pancreas       highly Respiratory respiratory tract larynx     highly

cell lineage
cell lines
fluid/secretion	serum

at STAGE

physiological period

ageing

Text	increased in senescent cells

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal sequence, highly conserved
	cysteine-rich N terminus of IGFBP motif
	kazal-type serine protease inhibitor domain

HOMOLOGY

interspecies

homolog to murine Igfbp7

Homologene

FAMILY

insulin-like growth factor binding protein family

CATEGORY

protooncogene , signaling growth factor

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	insuline-like growth factor binding protein 7 (related protein 1)
	prostacyclin stimulating factor tumor derived adhesion factor
	inducing senescence and apoptosis through autocrine/paracrine pathways
	stimulating BNIP3L transcription, at least in part, by increasing intracellular levels of SMARCB1, leading to formation of a SMARCB1-containing SWI/SNF chromatin-remodeling complex, recruited to the BNIP3L promoter and facilitates BNIP3L transcriptional activation
	factor required for an activated BRAF oncogene to induce senescence or apoptosis in primary human cells (Wajapeyee 2009)
	functions mostly independent of the IGF signaling pathway and acts as a tumor suppressor in multiple cancers (Huang 2010)
	can modulate the stimulatory effect of VEGF on angiogenesis by interfering with VEGF expression as well as VEGF signaling and not by inducing apoptosis (Tamura 2009)
	dispensable for BRAF(V600E)-induced senescence in human melanocytes (Scurr 2010)
	involved in several cellular processes, including proliferation, senescence and apoptosis (Vizioli 2010)

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

text	negative control

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

part of a pathway in which IGFBP7 increases expression of SMARCB1, which in turn leads to increased expression of BNIP3L culminating in apoptosis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function in renal clear cell carcinoma with poor prognosis tumoral     --over   in prostatic cancer tumoral     --low   is a critical step in melanoma genesis tumoral     --low   loss of expression has a functional role in thyroid carcinogenesis (Vizioli 2010)

Susceptibility

to autism spectrum disorder

Variant & Polymorphism other	functional variant -418G>C in the IGFBP7 promoter is associated with reduced risk of squamous cell carcinoma of head and neck, likely by enhancing the IGFBP7 promoter and DNA-protein binding activities (Huang 2010)

Candidate gene
Marker	MYH7, IGFBP7, ANXA2, and DES are all excellent candidate plasma biomarkers of heart failure
Therapy target	anticancer agent for treatment of metastatic melanoma and other cancers (Wajapeyee 2009)

ANIMAL & CELL MODELS