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FLASH GENE
Symbol IGFBP7 contributors: mct - updated : 17-01-2018
HGNC name insulin-like growth factor binding protein 7
HGNC id 5476
Location 4q12      Physical location : 57.897.245 - 57.976.539
Synonym name
  • prostacyclin-stimulating factor
  • angiomodulin
  • tumor-derived adhesion factor
  • PGI2-stimulating factor
  • MAC25 protein
    • Synonym symbol(s) ITGFBPRP1, MAC25, PSF, FSTL2, TAF, IBP-7, IGFBP-7v
    DNA
    TYPE functioning gene
    STRUCTURE 79.30 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure contains a consensus binding site for the dimeric AP1 (JUN/FOS) transcription factor
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1124 29 282 - Oh (1996)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     stomach   highly
    Endocrinepancreas   highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion serum
    at STAGE
    physiological period ageing
    Text increased in senescent cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal sequence, highly conserved
  • cysteine-rich N terminus of IGFBP motif
  • kazal-type serine protease inhibitor domain
    • HOMOLOGY
    interspecies homolog to murine Igfbp7
    Homologene
    FAMILY insulin-like growth factor binding protein family
    CATEGORY protooncogene , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • insuline-like growth factor binding protein 7 (related protein 1)
  • prostacyclin stimulating factor tumor derived adhesion factor
  • inducing senescence and apoptosis through autocrine/paracrine pathways
  • stimulating BNIP3L transcription, at least in part, by increasing intracellular levels of SMARCB1, leading to formation of a SMARCB1-containing SWI/SNF chromatin-remodeling complex, recruited to the BNIP3L promoter and facilitates BNIP3L transcriptional activation
  • factor required for an activated BRAF oncogene to induce senescence or apoptosis in primary human cells (Wajapeyee 2009)
  • functions mostly independent of the IGF signaling pathway and acts as a tumor suppressor in multiple cancers (Huang 2010)
  • can modulate the stimulatory effect of VEGF on angiogenesis by interfering with VEGF expression as well as VEGF signaling and not by inducing apoptosis (Tamura 2009)
  • dispensable for BRAF(V600E)-induced senescence in human melanocytes (Scurr 2010)
  • involved in several cellular processes, including proliferation, senescence and apoptosis (Vizioli 2010)
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text negative control
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • part of a pathway in which IGFBP7 increases expression of SMARCB1, which in turn leads to increased expression of BNIP3L culminating in apoptosis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in renal clear cell carcinoma with poor prognosis
    tumoral     --over  
    in prostatic cancer
    tumoral     --low  
    is a critical step in melanoma genesis
    tumoral     --low  
  • loss of expression has a functional role in thyroid carcinogenesis (Vizioli 2010)
    • Susceptibility to autism spectrum disorder
    Variant & Polymorphism other
  • functional variant -418G>C in the IGFBP7 promoter is associated with reduced risk of squamous cell carcinoma of head and neck, likely by enhancing the IGFBP7 promoter and DNA-protein binding activities (Huang 2010)
    • Candidate gene
    Marker
  • MYH7, IGFBP7, ANXA2, and DES are all excellent candidate plasma biomarkers of heart failure
    • Therapy target
  • anticancer agent for treatment of metastatic melanoma and other cancers (Wajapeyee 2009)
    • ANIMAL & CELL MODELS