basic FUNCTION
| playing a potential role in the regulation of apoptosis |
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inducing NFKB activation and required for the normal development of B cells and for the activation of the IKK complex |
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acting as a caspase |
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mediate additional functions related to T cell activation, cleaving both the ubiquitin editing enzyme, TNFAIP3, and the C terminus of BCL10 |
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have an essential role in antigen receptor-induced nuclear factor-KB (NF-KB) activation and the control of lymphocyte activation and proliferation |
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mediates antigen receptor signalling to NFKB1 by acting as a scaffold protein |
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role for MALT1 proteolytic activity in TCR-induced JNK activation and CYLD cleavage is the underlying mechanism |
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has many similarities to CASP8, even cleaving the putative target protein CYLD with comparable efficiencies, but with diametrically opposite primary substrate specificity |
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the catalytic activity of MALT1 promotes activation of canonical and non-canonical NFKB1 as well as other signalling pathways |
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protease activity of the paracaspase MALT1 is central to lymphocyte activation and lymphomagenesis |
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MALT1 protease activity is critical for controlling the mRNA stability of T cell effector genes. |
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mediates the activation of NFKB1 in response to antigen receptor signaling |
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paracaspase with structural similarity to caspases |
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CARD11/BCL10/MALT1 (CBM) signalosome mediates antigen receptor-induced NFKB1 signaling to regulate multiple lymphocyte functions |
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CARD11, BCL10, and MALT1, that have complex 5'UTRs and encode proteins with short half-lives, are involved in BCR signaling |
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central regulator of antigen receptor signaling that is frequently mutated in human lymphoma |
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differentially control lymphocyte differentiation and activation pathways and selective paracaspase blockage skews systemic immunity toward destructive autoinflammation |
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plays a key role in immunity and inflammation by regulating gene expression in lymphocytes and other immune cell types |
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novel role for MALT1 in CARD14-induced signaling |