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FLASH GENE
Symbol MYT1L contributors: mct/npt - updated : 03-05-2010
HGNC name myelin transcription factor 1-like
HGNC id 7623
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six C2Hc-type zinc fingers
    • HOMOLOGY
    interspecies homolog to murine Myt1l (93.5pc)
    homolog to rattus Myt1l (92.9pc)
    intraspecies paralog to MYT1
    Homologene
    FAMILY
  • myelin transcription factor 1 (Myt1) family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may favor the silencing of genes during neural development
  • may function as a panneural transcription factor associated with neuronal differentiation
  • may play a role in the development of neurons and oligodendrogalia in the CNS
  • with ASCL1 and POU3F2 could directly convert fibroblasts into neurons (Vierbuchen 2010)
  • may have a regulatory function in a specific phase during neuronal differentiation
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text developing nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacted with SIN3B, a protein that mediates transcriptional repression by binding to histone deacetylases (HDACs)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL2P25
    Susceptibility to schizophrenia
    Variant & Polymorphism other disrupted by rare CNVs in schizophrenia patients
    Candidate gene for intellectual disability in patients with 2p25.3 (2pter) deletions.
    Marker
    Therapy target
    ANIMAL & CELL MODELS