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FLASH GENE
Symbol TRIM35 contributors: mct - updated : 15-11-2017
HGNC name tripartite motif-containing 35
HGNC id 16285
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal RING zinc finger
  • a B box domain
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • a C terminal B30.2/SPRY domain
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Trim35 (81.7 pc)
    homolog to murine Trim35 (81.9 pc)
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-IV TRIM family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus,nucleoplasm,nuclear bodies
    text
  • under the influence of GATA1, TRIM35 relocates from cytoplasmic granules to the nucleus where it associates with both ZFPM1 and GATA1
    • basic FUNCTION
  • involved in protein ubiquitination
  • playing as role in apoptosis
  • under the influence of GATA1, TRIM35 relocates from cytoplasmic granules to the nucleus where it associates with both ZFPM1 and GATA1
  • is a novel tumor suppressor in hepatocellular carcinoma (HCC)
  • new function for TRIM35, which is to regulate the Warburg effect and tumorigenicity through interaction with PKM in HCC
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • TRIM35 interacts with PKM and the coiled-coil domain is required for such an interaction
  • TRIM35 inhibits phosphorylation of pyruvate kinase isoform M2 (PKM), which is involved in aerobic glycolysis of cancer cells
  • TRIM35 is a negative feedback regulator of TLR7/9-mediated type I IFN production due to its ability to suppress the stability of IRF7
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • PKM/TRIM35 expression could be a biomarker for the prognosis of hepatocellular carcinoma (HCC)
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    PKM/TRIM35 expression could be a target for cancer therapy
    ANIMAL & CELL MODELS