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FLASH GENE
Symbol TRIM35 contributors: mct - updated : 15-11-2017
HGNC name tripartite motif-containing 35
HGNC id 16285
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 26.43 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map pter - D8S1725 - D8S1771 - TRIM35 - D8S1839 - D8S1820 - cen
Authors UCSC (2009)
Physical map
NEFL 8p21 neurofilament, light polypeptide 68kDa LOC286061 8p21.2 hypothetical protein LOC286061 DOCK5 8p21.2 dedicator of cytokinesis 5 GNRH1 8p21-p12 gonadotropin-releasing hormone 1 (leutinizing-releasing hormone) KCTD9 8p21.1 potassium channel tetramerisation domain containing 9 CDCA2 8p12-21 cell division cycle associated 2 EBF2 8p21.1 early B-cell factor 2 PPP2R2A 8p21.1 protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform LOC157489 8p21.1 similar to hypothetical protein FLJ10498 BNIP3L 8p21 BCL2/adenovirus E1B 19kDa interacting protein 3-like PNMA2 8p21.1 paraneoplastic antigen MA2 LOC338097 8p21 proteasome activator subunit 2 pseudogene DPYSL2 8p21 dihydropyrimidinase-like 2 ADRA1A 8p21-p11.2 adrenergic, alpha-1A-, receptor LOC286129 8p21.1 similar to chromosome 15 open reading frame 2 STMN4 8P21.1 stathmin-like 4 TRIM35 8p21.1 tripartite motif-containing 35 PTK2B 8p21.1 PTK2B protein tyrosine kinase 2 beta CHRNA2 8p21 cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) EPHX2 8p21-p12 epoxide hydrolase 2, cytoplasmic GULOP 8p21.1 gulonolactone (L-) oxidase pseudogene CLU 8p21.3-p12 clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J) SCARA3 8p21 scavenger receptor class A, member 3 FLJ10853 8p21.1 hypothetical protein FLJ10853 LOC157570 8p21.1 hypothetical protein LOC157570 TOPK 8p21.2 hypothetical protein LOC157570 MGC45780 8p21.1 hypothetical protein MGC45780 LOC389643 8 hypothetical gene supported by AK129923 ELP3 8p21.1 elongation protein 3 homolog (S. cerevisiae) LOC389644 8 similar to 60S ribosomal protein L5 LOC346848 8p21.1 similar to 60S RIBOSOMAL PROTEIN L5 PNOC 8p21 prepronociceptin DKFZp434K1210 8p21.1 hypothetical protein DKFZp434K1210 PBF 8p21.1 papillomavirus regulatory factor PRF-1 FBXO16 8p21.1 F-box only protein 16 FZD3 8p21 frizzled homolog 3 (Drosophila) EXTL3 8p21 exostoses (multiple)-like 3 FLJ10871 8p21.1 hypothetical protein FLJ10871 FLJ21616 8p21.1 hypothetical protein FLJ21616 KIF13B 8p21-p12 kinesin family member 13B DUSP4 8p12-p11 dual specificity phosphatase 4
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 4247 56.4 493 - 2003 12692137
4 - 4128 - 266 - 2003 12692137
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue   
Endocrinepancreas    
Reproductivefemale systemuterus   
Respiratorylung    
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text branchial arches, spinal cord, dorsal root ganglia, limb buds, brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal RING zinc finger
  • a B box domain
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • a C terminal B30.2/SPRY domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Trim35 (81.7 pc)
    homolog to murine Trim35 (81.9 pc)
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-IV TRIM family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus,nucleoplasm,nuclear bodies
    text
  • under the influence of GATA1, TRIM35 relocates from cytoplasmic granules to the nucleus where it associates with both ZFPM1 and GATA1
  • basic FUNCTION
  • involved in protein ubiquitination
  • playing as role in apoptosis
  • under the influence of GATA1, TRIM35 relocates from cytoplasmic granules to the nucleus where it associates with both ZFPM1 and GATA1
  • is a novel tumor suppressor in hepatocellular carcinoma (HCC)
  • new function for TRIM35, which is to regulate the Warburg effect and tumorigenicity through interaction with PKM in HCC
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • TRIM35 interacts with PKM and the coiled-coil domain is required for such an interaction
  • TRIM35 inhibits phosphorylation of pyruvate kinase isoform M2 (PKM), which is involved in aerobic glycolysis of cancer cells
  • TRIM35 is a negative feedback regulator of TLR7/9-mediated type I IFN production due to its ability to suppress the stability of IRF7
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • PKM/TRIM35 expression could be a biomarker for the prognosis of hepatocellular carcinoma (HCC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    PKM/TRIM35 expression could be a target for cancer therapy
    ANIMAL & CELL MODELS