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FLASH GENE

Symbol

TRIM35

contributors: mct - updated : 15-11-2017

HGNC name	tripartite motif-containing 35
HGNC id	16285

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8p21.2      Physical location : 27.142.403 - 27.168.834
Synonym name	zinc finger C3-H-C4 type
	macrophage-derived apoptosis-inducing RBCC protein
	hemopoietic lineage switch protein 5
Synonym symbol(s)	KIAA1098, HLS5, MAIR, MGC17233

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head
STRUCTURE	26.43 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	pter - D8S1725 - D8S1771 - TRIM35 - D8S1839 - D8S1820 - cen
Authors	UCSC (2009)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_171982 6 - 4247 NP_741983 56.4 493 - 2003 12692137 NM_001304495 4 - 4128 NP_001291424 - 266 - 2003 12692137

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue       Endocrine pancreas         Reproductive female system uterus       Respiratory lung         Visual eye

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	branchial arches, spinal cord, dorsal root ganglia, limb buds, brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal RING zinc finger
	a B box domain
	a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
	a C terminal B30.2/SPRY domain

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to rattus Trim35 (81.7 pc)
	homolog to murine Trim35 (81.9 pc)

Homologene

FAMILY	TRIM/RBCC family
	C-IV TRIM family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,granule
	intracellular,nucleus,nucleoplasm,nuclear bodies
text	under the influence of GATA1, TRIM35 relocates from cytoplasmic granules to the nucleus where it associates with both ZFPM1 and GATA1

basic FUNCTION	involved in protein ubiquitination
	playing as role in apoptosis
	under the influence of GATA1, TRIM35 relocates from cytoplasmic granules to the nucleus where it associates with both ZFPM1 and GATA1
	is a novel tumor suppressor in hepatocellular carcinoma (HCC)
	new function for TRIM35, which is to regulate the Warburg effect and tumorigenicity through interaction with PKM in HCC

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein	TRIM35 interacts with PKM and the coiled-coil domain is required for such an interaction
	TRIM35 inhibits phosphorylation of pyruvate kinase isoform M2 (PKM), which is involved in aerobic glycolysis of cancer cells
	TRIM35 is a negative feedback regulator of TLR7/9-mediated type I IFN production due to its ability to suppress the stability of IRF7

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	PKM/TRIM35 expression could be a biomarker for the prognosis of hepatocellular carcinoma (HCC)
Therapy target
	System Type Disorder Pubmed cancer digestive liver PKM/TRIM35 expression could be a target for cancer therapy

ANIMAL & CELL MODELS