Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

HCN4

contributors: mct/npt - updated : 17-03-2017

HGNC name	hyperpolarization activated cyclic nucleotide-gated potassium channel 4
HGNC id	16882

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

FSBD , BRGS8

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation     loss of function with sinus nodal dysfunction, QT prolongation and polymorphic ventricular tachycardia

Susceptibility

to Atrial fibrillation (AF)

Variant & Polymorphism other	HCN4 haploinsufficiency is the likely mechanism for early-onset AF in the p.Pro257Ser carrier

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS