| 1 | HCN1, HCN2, HCN4
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| Loss of HCN2 leads to delayed gastrointestinal motility and reduced energy intake in mice.
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| Fisher DW, Luu P, Agarwal N, Kurz JE, Chetkovich DM.
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| PLoS One 13(2):e0193012. doi: 10.1371/journal.pone.0193012. eCollection 2018.
2018
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| 2 | FSBD, HCN4
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| Clinical phenotype of HCN4-related sick sinus syndrome.
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| Raucci FJ Jr, Shoemaker MB, Knollmann BC.
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| Heart Rhythm eart Rhythm. 2017 Feb 14. pii: S1547-5271(17)30164-9. doi: 10.1016/j.hrthm.2017.02.006. [Epub ahead of print] No abstract availa 2017
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| 3 | FSBD, HCN4
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| Sick sinus syndrome with HCN4 mutations shows early onset and frequent association with atrial fibrillation and left ventricular noncompaction.
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| Ishikawa T, Ohno S, Murakami T, Yoshida K, Mishima H, Fukuoka T, Kimoto H, Sakamoto R, Ohkusa T, Aiba T, Nogami A, Sumitomo N, Shimizu W, Yoshiura KI, Horigome H, Horie M, Makita N.
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| Heart Rhythm eart Rhythm. 2017 Jan 17. pii: S1547-5271(17)30067-X. doi: 10.1016/j.hrthm.2017.01.020. [Epub ahead of print]
2017
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| 4 | HCN1, HCN2, HCN3, HCN4
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| Expression and cellular localization of HCN channels in rat cerebellar granule neurons.
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| Zúñiga R, González D, Valenzuela C, Brown N, Zúñiga L.
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| Biochem Biophys Res Commun 478(3):1429-35. doi: 10.1016/j.bbrc.2016.08.141. Epub 2016 Aug 25.
2016
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| 5 | FSBD, HCN4
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| HCN4 mutation as a molecular explanation on patients with bradycardia and non-compaction cardiomyopathy.
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| Millat G, Janin A, de Tauriac O, Roux A, Dauphin C.
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| Eur J Med Genet 58(9):439-42. doi: 10.1016/j.ejmg.2015.06.004.
2015
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| 6 | HCN1, HCN2, HCN4
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| Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse.
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| Seo H, Seol MJ, Lee K.
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| Mol Brain 8:13. doi: 10.1186/s13041-015-0103-4.
2015
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| 7 | FSBD, HCN4
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| HCN4 mutations in multiple families with bradycardia and left ventricular noncompaction cardiomyopathy.
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| Milano A, Vermeer AM, Lodder EM, Barc J, Verkerk AO, Postma AV, van der Bilt IA, Baars MJ, van Haelst PL, Caliskan K, Hoedemaekers YM, Le Scouarnec S, Redon R, Pinto YM, Christiaans I, Wilde AA, Bezzina CR.
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| J Am Coll Cardiol 64(8):745-56. doi: 10.1016/j.jacc.2014.05.045.
2014
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| 8 | FSBD, HCN4
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| The symptom complex of familial sinus node dysfunction and myocardial noncompaction is associated with mutations in the HCN4 channel.
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| Schweizer PA, Schröter J, Greiner S, Haas J, Yampolsky P, Mereles D, Buss SJ, Seyler C, Bruehl C, Draguhn A, Koenen M, Meder B, Katus HA, Thomas D.
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| J Am Coll Cardiol 64(8):757-67. doi: 10.1016/j.jacc.2014.06.1155.
2014
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| 9 | HCN4
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| A novel trafficking-defective HCN4 mutation is associated with early-onset atrial fibrillation.
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| Macri V, Mahida SN, Zhang ML, Sinner MF, Dolmatova EV, Tucker NR, McLellan M, Shea MA, Milan DJ, Lunetta KL, Benjamin EJ, Ellinor PT.
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| Heart Rhythm 11(6):1055-62. doi: 10.1016/j.hrthm.2014.03.002.
2014
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| 10 | HCN4, TRPM7
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| Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity.
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| Sah R, Mesirca P, Van den Boogert M, Rosen J, Mably J, Mangoni ME, Clapham DE.
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| Proc Natl Acad Sci U S A 110(32):E3037-46. doi: 10.1073/pnas.1311865110. Epub 2013 Jul 22.
2013
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| 11 | CAV3, HCN4
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| Molecular and functional evidence of HCN4 and caveolin-3 interaction during cardiomyocyte differentiation from human embryonic stem cells.
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| Bosman A, Sartiani L, Spinelli V, Del Lungo M, Stillitano F, Nosi D, Mugelli A, Cerbai E, Jaconi M.
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| Stem Cells Dev 22(11):1717-27. doi: 10.1089/scd.2012.0247.
2013
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| 12 | HCN4
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| A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells.
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| Später D, Abramczuk MK, Buac K, Zangi L, Stachel MW, Clarke J, Sahara M, Ludwig A, Chien KR.
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| Nat Cell Biol 15(9):1098-106. doi: 10.1038/ncb2824.
2013
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| 13 | HCN4, THY1
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| Thy1 associates with the cation channel subunit HCN4 in adult rat retina.
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| Partida GJ, Stradleigh TW, Ogata G, Godzdanker I, Ishida AT.
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| Invest Ophthalmol Vis Sci 53(3):1696-703. Print 2012 Mar.
2012
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| 14 | HCN4
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| A caveolin-binding domain in the HCN4 channels mediates functional interaction with caveolin proteins.
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| Barbuti A, Scavone A, Mazzocchi N, Terragni B, Baruscotti M, Difrancesco D.
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| J Mol Cell Cardiol 53(2):187-95. doi: 10.1016/j.yjmcc.2012.05.013.
2012
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| 15 | HCN4, IRX6, RCVRN, TACR3, VSX1
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| Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6.
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| Star EN, Zhu M, Shi Z, Liu H, Pashmforoush M, Sauve Y, Bruneau BG, Chow RL.
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| Development 139(24):4644-55. doi: 10.1242/dev.081729.
2012
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| 16 | HCN4
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| Colocalization of hyperpolarization-activated, cyclic nucleotide-gated channel subunits in rat retinal ganglion cells.
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| Stradleigh TW, Ogata G, Partida GJ, Oi H, Greenberg KP, Krempely KS, Ishida AT.
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| J Comp Neurol 519(13):2546-73. doi: 10.1002/cne.22638.
2011
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| 17 | HCN4
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| Tissue-specific N terminus of the HCN4 channel affects channel activation.
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| Liu H, Aldrich RW.
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| J Biol Chem 286(16):14209-14. doi: 10.1074/jbc.M110.215640.
2011
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| 18 | HCN1, HCN2, HCN4
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| Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.
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| Herrmann S, Layh B, Ludwig A.
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| J Mol Cell Cardiol 51(6):997-1006. doi: 10.1016/j.yjmcc.2011.09.005. Epub 2011 Sep 14.
2011
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| 19 | HCN2, HCN4
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| Control of heart rate by cAMP sensitivity of HCN channels.
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| Alig J, Marger L, Mesirca P, Ehmke H, Mangoni ME, Isbrandt D.
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| Proc Natl Acad Sci U S A 106(29):12189-94. Epub 2009 Jul 1.
2009
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| 20 | HCN1, HCN2, HCN3, HCN4
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| Low-conductance HCN1 ion channels augment the frequency response of rod and cone photoreceptors.
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| Barrow AJ, Wu SM.
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| J Neurosci 29(18):5841-53.PMID: 19420251 2009
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| 21 | HCN1, HCN2, HCN3, HCN4
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| HCN channels: structure, cellular regulation and physiological function.
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| Wahl-Schott C, Biel M.
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| Cell Mol Life Sci 66(3):470-94. Review.PMID: 18953682 2009
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| 22 | BRGS8, HCN4
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| Role of HCN4 channel in preventing ventricular arrhythmia.
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| Ueda K, Hirano Y, Higashiuesato Y, Aizawa Y, Hayashi T, Inagaki N, Tana T, Ohya Y, Takishita S, Muratani H, Hiraoka M, Kimura A.
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| J Hum Genet 54(2):115-21. doi: 10.1038/jhg.2008.16. Epub 2009 Jan 23.
2009
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| 23 | HCN1, HCN2, HCN3, HCN4
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| Role of the hyperpolarization-activated current Ih in somatosensory neurons.
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| Momin A, Cadiou H, Mason A, McNaughton PA.
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| J Physiol 586(Pt 24):5911-29. Epub 2008 Oct 20.PMID: 18936078 2008
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| 24 | FSBD, HCN4
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| Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia.
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| Nof E, Luria D, Brass D, Marek D, Lahat H, Reznik-Wolf H, Pras E, Dascal N, Eldar M, Glikson M.
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| Circulation 116(5):463-70. Epub 2007 Jul 23.
2007
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| 25 | HCN4, FSBD
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| Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel.
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| Milanesi R, Baruscotti M, Gnecchi-Ruscone T, DiFrancesco D.
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| N Engl J Med 354(2):151-7. 2006
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| 26 | HCN1, HCN2, HCN3, HCN4
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| Functional expression of the human HCN3 channel.
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| Stieber J, Stöckl G, Herrmann S, Hassfurth B, Hofmann F.
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| J Biol Chem 280(41):34635-43. Epub 2005 Jul 25.PMID: 16043489 2005
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| 27 | HCN4
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| Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia.
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| Ueda K, Nakamura K, Hayashi T, Inagaki N, Takahashi M, Arimura T, Morita H, Higashiuesato Y, Hirano Y, Yasunami M, Takishita S, Yamashina A, Ohe T, Sunamori M, Hiraoka M, Kimura A.
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| J Biol Chem 279(26):27194-8. Epub 2004 Apr 30. 2004
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| 28 | HCN2, HCN4
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| Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4.
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| Stieber J, Thomer A, Much B, Schneider A, Biel M, Hofmann F.
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| J Biol Chem 278(36):33672-80. Epub 2003 Jun 17. 2003
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| 29 | HCN2, HCN4
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| Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells.
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| Qu J, Altomare C, Bucchi A, DiFrancesco D, Robinson RB.
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| Pflugers Arch 444(5):597-601. Epub 2002 Jun 12.
2002
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| 30 | HCN4
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| Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis.
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| Seifert R, et al.
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| Proc Natl Acad Sci U S A 96(16):9391-6. 1999
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