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FLASH GENE

Symbol

SSTR2

contributors: mct - updated : 15-09-2015

HGNC name	somatostatin receptor 2
HGNC id	11331

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in pancreatic cancer cells, benign prostatic hyperplasia (BPH) tumoral     --over   in T-leukaemia cell lines tumoral     --over   by estrogen in breast cancer cells constitutional       loss of function early loss of function may be associated with the selective vulnerability of the noradrenergic system in Alzheimer disease tumoral     --low   with PLAGL1, are underexpressed in non-functioning pituitary adenomas (NFPA), compared to somatotropinomas and normal pituitaries tumoral     --low   significantly methylated in Colorectal cancer tissues when compared with adjacent normal colorectal tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	use of liver tissue SSTR2 protein and mRNA is a reliable tumor marker for liver cancer rather than AFP which is always misleading during silent stages of hepatocarcinogenesis
	with CMTM3, and MDFI having a potential role as biomarkers for colorectal cancer
Therapy target
	System Type Disorder Pubmed cancer thyroid   valid target for treatment of thyroid tumours cancer hemopathy   useful targets for therapy during inflammatory diseases and malignancies affecting lymphocytesuseful targets for therapy during inflammatory diseases and malignancies affecting lymphocytes cardiovascular cardiomyopathy   cardiac protective role of SSTR2 via modulation of Ca(2+) associated signaling pathways attributed to cardiac hypertrophy

ANIMAL & CELL MODELS