Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ERLIN2 contributors: npt/shn/mct - updated : 06-01-2016
HGNC name ER lipid raft associated 2
HGNC id 1356
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extreme N-terminus of ERLIN2 were found to be sufficient for heterologous targeting of GFP to the ER in the absence of classical ER retrieval motifs
  • a SPFH domain
    • HOMOLOGY
    interspecies ortholog to Erlin2, Mus musculus
    ortholog to Erlin2, Rattus norvegicus
    ortholog to erlin2, Danio rerio
    ortholog to ERLIN2, Pan troglodytes
    Homologene
    FAMILY
  • prohibitin domain containing family of proteins
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • reside in detergent resistant membranes (DRMs) in the ER
    • basic FUNCTION
  • a mediator of the endoplasmic reticulum degradation (ERAD) pathway
  • ERLIN1/ERLIN2 complex is a factor that selectively mediates the ERAD of activated IP(3) receptors
  • novel mediator of ER-associated degradation
  • is a novel oncogenic factor associated with the ER stress response pathway
  • may confer a selective growth advantage for breast cancer cells by facilitating a cytoprotective response to various cellular stresses associated with oncogenesis
  • is a regulator of cytosolic lipid content in cancer cells has important implications for understanding the molecular basis of tumorigenesis and the treatment of cancer
  • gamma-secretase associated protein (GSAP), residing in detergent resistant membranes (DRMs) in the ER
  • ERLIN1, ERLIN2 promote stability of the SREBF-SCAP-INSIG complex and may contribute to the highly cooperative control of this system
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ERLIN1/2 complex is composed of an assemblage of lower-order hetero-oligomers, probably heterotrimers, linked together by assembly domain hydrophobic AAs
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • form a heterodimer with SPFH1 (
  • ER membrane proteins, ERLIN2 and TMUB1, are associated proteins of mammalian AMFR, a membrane-bound ubiquitin ligase that mediates sterol-accelerated ERAD of the cholesterol biosynthetic enzyme HMGCR
  • associated with active gamma-secretase in brain tissue (GSAP)
  • interacts with gamma-secretase in brain, and reduces APP production while the effect on notch processing is limited
  • multimeric ER proteins ERLIN1 and ERLIN2 are additional SREBF1, SREBF2 regulators
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IDMDC , SPG18 , PLSJ2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of ZNF703, ERLIN2, PROSC, GPR124, and BRF2 in urothelial carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativealzheimer
    interfering with the ERLIN2/gamma-secretase interaction might reduce APP production without affecting Notch processing, and thus be a pharmacological strategy for treatment of AD
    ANIMAL & CELL MODELS