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FLASH GENE

Symbol

SEPTIN9

contributors: mct/npt - updated : 22-01-2019

HGNC name	septin 9
HGNC id	7323

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HNA

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25). tumoral     --over   in diverses tumors tumoral fusion       with MLL in acute myeloid leukemia tumoral   deletion     in sporadic epithelial ovarian tumors tumoral     --low   by hypermethylation in the progression of colon neoplastic disease

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	novel approach for the early detection of CRC, using SEPT9 promoter methylation, micronuclei frequency and genotypes, with the potential to improve Colorectal Cancer (CRC) risk assessment
Therapy target
	System Type Disorder Pubmed cancer reproductive breast promising tool in breast cancer detection and further emphasize the importance of analyzing and targeting SEPT9 isoform-specific expression and function digestive liver steatosis pharmacological agents that inhibit SEPT9 methylation and increase its expression could be considered as valuable treatments for liver fibrosis

ANIMAL & CELL MODELS