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FLASH GENE
Symbol SEPTIN9 contributors: mct/npt - updated : 22-01-2019
HGNC name septin 9
HGNC id 7323
ASSOCIATED DISORDERS
corresponding disease(s) HNA
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   translocation    
in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25).
tumoral     --over  
in diverses tumors
tumoral fusion      
with MLL in acute myeloid leukemia
tumoral   deletion    
in sporadic epithelial ovarian tumors
tumoral     --low  
by hypermethylation in the progression of colon neoplastic disease
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • novel approach for the early detection of CRC, using SEPT9 promoter methylation, micronuclei frequency and genotypes, with the potential to improve Colorectal Cancer (CRC) risk assessment
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    promising tool in breast cancer detection and further emphasize the importance of analyzing and targeting SEPT9 isoform-specific expression and function
    digestiveliversteatosis
    pharmacological agents that inhibit SEPT9 methylation and increase its expression could be considered as valuable treatments for liver fibrosis
    ANIMAL & CELL MODELS