| protein
| binding IFNA by ISRE (IFN stimulated response element) |
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TAK1-JNK cascade is required for IRF3 function  |
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TRIM21 (tripartite motif-containing 21) is significantly induced and interacts with IRF3 upon RNA virus infection |
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possible function for TRAF5 in mediating the activation of IRF3 and NF-kappaB downstream of MAVS through the recruitment of IKBKG |
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interaction with HERC5 (positive regulator of antiviral innate immune responses, which maintains IRF3 stability via catalyzing ISGylation of IRF3) |
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NR2C2 can stimulate IRF3 phosphorylation via JNK |
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requirement for IRF3, a master regulator of IFNB1 production, as a previously un-indentified interaction partner of IRF8 |
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interaction with E2F1 (E2F1 negatively regulates IRF3 transcription through binding to the E2F consensus binding site) |
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interacting with CASP8 (CASP8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3) |
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basal expression level of IRF3 is regulated by transcription factors SP1 and SP3 |
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IRF3 indeed activates the gene promoter of TSLP via IRF-binding sequences |
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MRE11A physically interacted with dsDNA in the cytoplasm and was required for activation of TMEM173 and IRF3 |
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DDX3X is a scaffolding adaptor that directly facilitates phosphorylation of IRF3 by IKBKE and might thus be involved in pathway-specific activation of IRF3 |
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FOXO1 interacted with IRF3 in a viral infection-dependent manner and promoted K48-linked polyubiquitination and degradation of IRF3 in the cytosol |
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phosphorylation of TMEM173 on S366 strongly prevents the transcriptional activity of IRF3 |
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CGAS-induced activation of TMEM173 also involves the activation of the NFKB1 and IRF3 pathways |
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endogenous optineurin is dispensable for NFKB activation but necessary for optimal IRF3 activation in immune cells |
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TBK1 is a downstream kinase controlling dsDNA-mediated IRF3 and NFKB1 signaling dependent on TMEM173 |
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HSPD1 interacted with IRF3 and it contributed to the induction of IFNB1 |
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exerts its antiviral activity mainly through governing its downstream regulators DDX58 and IFIH1 by gene splicing to activate IRF3 and induce classical ISG expression independent of the JAT-STAT signaling pathway |
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HAVCR2-signaling inhibited phosphorylation of IRF3, a TLR4 downstream transcriptional factor regulating macrophage polarization |
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SNRNP200 promotes viral RNA sensing and IRF3 activation through the ability of its N-terminal Sec63 domain (Sec63-1) to bind RNA and to interact with TBK1 |
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IRF3 is an important regulator of ORMDL3 induction following RSV infection by binding directly to the promoter of ORMDL3, which may be implicated in the inflammatory and immune reactions involved in bronchiolitis and wheezing diseases |
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RUBCN interacts with IRF3 and ultimately this interaction leads to inhibition of the dimerization of IRF3 |
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SNF8 is an endosomal sorting complex required for transport (ESCRT)-II subunit, as an essential factor controlling IRF3-dependent antiviral defense |
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NSD3 is the lysine methyltransferase that directly binds to the IRF3 C-terminal region through its PWWP1 domain and methylates IRF3 at K366 via its SET domain |
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IRF3 and IRF7 bind to many interferon-stimulated response element (ISRE)-type sites in the virus-response elements (VREs) of IFN promoters |
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ANKRD1 is involved in IRF3-mediated antiviral innate immune signaling pathways |
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TMEM173 promoted the transcriptional activity of ORMDL3, which was significantly associated with increased levels of interferon regulatory factor 3 (IRF3) and signal transducer and activator of transcription 6 (STAT6) |
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USP22 promoted nuclear translocation of IRF3 by deubiquitianting and stabilizing KPNA2 after viral infection |
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mechanistic link between USP22 and IRF3 nuclear translocation that expands potential therapeutic strategies for infectious diseases |
