| 1 | IRF3, KPNA2, USP22
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| USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2
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| Cai Z, Zhang MX, Tang Z, Zhang Q, Ye J, Xiong TC, Zhang ZD, Zhong B.
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| J Exp Med. May 4;217(5):e20191174. doi: 10.1084/jem.20191174 2020
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| 2 | IRF3, IRF5, IRF7
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| DNA-binding landscape of IRF3, IRF5 and IRF7 dimers: implications for dimer-specific gene regulation.
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| Andrilenas KK, Ramlall V, Kurland J, Leung B, Harbaugh AG, Siggers T.
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| Nucleic Acids Res ucleic Acids Res. 2018 Jan 18. doi: 10.1093/nar/gky002. [Epub ahead of print]
2018
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| 3 | ANKRD1, IRF3
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| Ankyrin repeat domain 1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum.
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| Bin L, Li X, Richers B, Streib JE, Hu JW, Taylor P, Leung DYM.
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| J Allergy Clin Immunol 141(6):2085-2093.e1. doi: 10.1016/j.jaci.2018.01.001. Epub 2018 Jan 31.
2018
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| 4 | IRF3, ORMDL3
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| Mechanisms and roles by which IRF-3 mediates the regulation of ORMDL3 transcription in respiratory syncytial virus infection.
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| Wang XH, Shu J, Jiang CM, Zhuang LL, Yang WX, Zhang HW, Wang LL, Li L, Chen XQ, Jin R, Zhou GP.
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| Int J Biochem Cell Biol 87:8-17. doi: 10.1016/j.biocel.2017.03.007. Epub 2017 Mar 20.
2017
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| 5 | IRF3, RUBCN
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| Rubicon Modulates Antiviral Type I Interferon (IFN) Signaling by Targeting IFN Regulatory Factor 3 Dimerization.
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| Kim JH, Kim TH, Lee HC, Nikapitiya C, Uddin MB, Park ME, Pathinayake P, Lee ES, Chathuranga K, Herath TUB, Chathuranga WAG, Lee JS.
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| J Virol 91(14). pii: e00248-17. doi: 10.1128/JVI.00248-17. Print 2017 Jul 15.
2017
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| 6 | IRF3, NSD3
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| The methyltransferase NSD3 promotes antiviral innate immunity via direct lysine methylation of IRF3.
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| Wang C, Wang Q, Xu X, Xie B, Zhao Y, Li N, Cao X.
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| J Exp Med. Dec 4;214(12):3597-3610. doi: 10.1084/jem.20170856. Epub 2017 Nov 3. 2017
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| 7 | IRF3, SNF8
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| Pivotal role for the ESCRT-II complex subunit EAP30/SNF8 in IRF3-dependent innate antiviral defense.
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| Kumthip K, Yang D, Li NL, Zhang Y, Fan M, Sethuraman A, Li K.
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| PLoS Pathog. Oct 30;13(10):e1006713. doi: 10.1371/journal.ppat.1006713. 2017
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| 8 | IRF3, SNRNP200, TBK1
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| Spliceosome SNRNP200 Promotes Viral RNA Sensing and IRF3 Activation of Antiviral Response.
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| Tremblay N, Baril M, Chatel-Chaix L, Es-Saad S, Park AY, Koenekoop RK, Lamarre D.
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| PLoS Pathog 12(7):e1005772. doi: 10.1371/journal.ppat.1005772. eCollection 2016 Jul. Erratum in: PLoS Pathog. 2017 Jan 24;13(1):e1006174.
2016
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| 9 | HAVCR2, IRF3, TLR4
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| Tim-3 promotes intestinal homeostasis in DSS colitis by inhibiting M1 polarization of macrophages.
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| Jiang X, Yu J, Shi Q, Xiao Y, Wang W, Chen G, Zhao Z, Wang R, Xiao H, Hou C, Feng J, Ma Y, Shen B, Wang L, Li Y, Han G.
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| Clin Immunol 160(2):328-35. doi: 10.1016/j.clim.2015.07.008. Epub 2015 Jul 21.
2015
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| 10 | DDX58, EFTUD2, IFIH1, IRF3
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| EFTUD2 Is a Novel Innate Immune Regulator Restricting Hepatitis C Virus Infection through the RIG-I/MDA5 Pathway.
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| Zhu C, Xiao F, Hong J, Wang K, Liu X, Cai D, Fusco DN, Zhao L, Jeong SW, Brisac C, Chusri P, Schaefer EA, Zhao H, Peng LF, Lin W, Chung RT.
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| J Virol 89(13):6608-18. doi: 10.1128/JVI.00364-15. Epub 2015 Apr 15.
2015
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| 11 | IRF3, STING1, TBK1
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| Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-κB activation through TBK1.
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| Abe T, Barber GN.
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| J Virol 88(10):5328-41. doi: 10.1128/JVI.00037-14. Epub 2014 Mar 5. 2014
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| 12 | HSPD1, IFNB1, IRF3
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| HSPD1 interacts with IRF3 to facilitate interferon-beta induction.
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| Lin L, Pan S, Zhao J, Liu C, Wang P, Fu L, Xu X, Jin M, Zhang A.
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| PLoS One 9(12):e114874. doi: 10.1371/journal.pone.0114874. eCollection 2014.
2014
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| 13 | FOXO1, IRF3
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| FoxO1 negatively regulates cellular antiviral response by promoting degradation of IRF3.
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| Lei CQ, Zhang Y, Xia T, Jiang LQ, Zhong B, Shu HB.
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| J Biol Chem 288(18):12596-604. doi: 10.1074/jbc.M112.444794. Epub 2013 Mar 26.
2013
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| 14 | DDX3X, IKBKE, IRF3
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| Human DEAD box helicase 3 couples IκB kinase ε to interferon regulatory factor 3 activation.
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| Gu L, Fullam A, Brennan R, Schröder M.
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| Mol Cell Biol 33(10):2004-15. doi: 10.1128/MCB.01603-12. Epub 2013 Mar 11.
2013
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| 15 | IRF3, STING1, TBK1, ULK1
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| Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling.
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| Konno H, Konno K, Barber GN.
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| Cell 155(3):688-98. doi: 10.1016/j.cell.2013.09.049. Epub 2013 Oct 10. 2013
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| 16 | IRF3, OPTN
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| Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells.
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| Munitic I, Giardino Torchia ML, Meena NP, Zhu G, Li CC, Ashwell JD.
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| J Immunol 191(12):6231-40. doi: 10.4049/jimmunol.1301696. Epub 2013 Nov 15.
2013
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| 17 | CGAS, IRF3, STING1
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| Structural and functional analyses of DNA-sensing and immune activation by human cGAS.
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| Kato K, Ishii R, Goto E, Ishitani R, Tokunaga F, Nureki O.
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| PLoS One 8(10):e76983. doi: 10.1371/journal.pone.0076983. eCollection 2013. 2013
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| 18 | IRF3, SP1
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| Characterization of a spliced variant of human IRF-3 promoter and its regulation by the transcription factor Sp1.
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| Ren W, Zhu LH, Xu HG, Jin R, Zhou GP.
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| Mol Biol Rep 39(6):6987-93. Epub 2012 Feb 4.
2012
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| 19 | IRF3, SP1, SP3
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| Transcription factors Sp1 and Sp3 regulate basal transcription of the human IRF-3 gene.
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| Xu HG, Jin R, Ren W, Zou L, Wang Y, Zhou GP.
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| Biochimie 94(6):1390-7. doi: 10.1016/j.biochi.2012.03.011. Epub 2012 Mar 17.
2012
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| 20 | E2F1, IRF3
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| Direct repression of the human IRF-3 promoter by E2F1.
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| Xu HG, Ren W, Zou L, Wang Y, Jin R, Zhou GP.
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| Immunogenetics 63(4):189-96. Epub 2011 Jan 12.
2011
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| 21 | IRF3, IRF8
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| IRF8 and IRF3 cooperatively regulate rapid interferon-β induction in human blood monocytes.
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| Li P, Wong JJ, Sum C, Sin WX, Ng KQ, Koh MB, Chin KC.
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| Blood 117(10):2847-54. Epub 2011 Jan 12.
2011
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| 22 | CASP8, DDX58, IRF3, RIPK1
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| RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein.
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| Rajput A, Kovalenko A, Bogdanov K, Yang SH, Kang TB, Kim JC, Du J, Wallach D.
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| Immunity 34(3):340-51.
2011
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| 23 | IRF3
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| Identification of novel alternative splicing variants of interferon regulatory factor 3.
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| Li Y, Hu X, Song Y, Lu Z, Ning T, Cai H, Ke Y.
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| Biochim Biophys Acta 1809(3):166-75. Epub 2011 Jan 28.
2011
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| 24 | CASP8, IRF3
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| Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradation.
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| Sears N, Sen GC, Stark GR, Chattopadhyay S.
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| J Biol Chem 286(38):33037-44. Epub 2011 Aug 4.
2011
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| 25 | HERC5, IRF3, ISG15
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| Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification.
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| Shi HX, Yang K, Liu X, Liu XY, Wei B, Shan YF, Zhu LH, Wang C.
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| Mol Cell Biol 30(10):2424-36. Epub 2010 Mar 22.PMID: 20308324 2010
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| 26 | IRF3
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| Pathogen specific, IRF3-dependent signaling and innate resistance to human kidney infection.
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| Fischer H, Lutay N, Ragnarsdóttir B, Yadav M, Jönsson K, Urbano A, Al Hadad A, Rämisch S, Storm P, Dobrindt U, Salvador E, Karpman D, Jodal U, Svanborg C.
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| PLoS Pathog 6(9):e1001109.
2010
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| 27 | IRF3
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| Identification of a novel in vivo virus-targeted phosphorylation site in interferon regulatory factor-3 (IRF3).
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| Bergstroem B, Johnsen IB, Nguyen TT, Hagen L, Slupphaug G, Thommesen L, Anthonsen MW.
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| J Biol Chem 285(32):24904-14. Epub 2010 May 28.
2010
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| 28 | IRF3
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| Viral apoptosis is induced by IRF-3-mediated activation of Bax.
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| Chattopadhyay S, Marques JT, Yamashita M, Peters KL, Smith K, Desai A, Williams BR, Sen GC.
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| EMBO J 29(10):1762-73. Epub 2010 Apr 1.
2010
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| 29 | IRF3
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| Aberrant expression of interferon regulatory factor 3 in human lung cancer.
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| Tokunaga T, Naruke Y, Shigematsu S, Kohno T, Yasui K, Ma Y, Chua KJ, Katayama I, Nakamura T, Hishikawa Y, Koji T, Yatabe Y, Nagayasu T, Fujita T, Matsuyama T, Hayashi H.
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| Biochem Biophys Res Commun 397(2):202-7. Epub 2010 May 23.
2010
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| 30 | IRF3
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| Characterization of the human IRF-3 promoter and its regulation by the transcription factor E2F1.
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| Xu HG, Ren W, Lu C, Zhou GP.
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| Mol Biol Rep 37(7):3073-80. Epub 2009 Oct 14.
2010
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| 31 | IRF3, MAVS, TRAF5
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| TRAF5 is a downstream target of MAVS in antiviral innate immune signaling.
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| Tang ED, Wang CY.
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| PLoS One 5(2):e9172. doi: 10.1371/journal.pone.0009172.
2010
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| 32 | IRF3
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| The TAK1-JNK cascade is required for IRF3 function in the innate immune response.
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| Zhang B, Li M, Chen L, Yang K, Shan Y, Zhu L, Sun S, Li L, Wang C.
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| Cell Res 19(4):412-28.
2009
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| 33 | IRF3, TBK1
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| TANK-binding kinase-1 plays an important role during in vitro and in vivo type I IFN responses to DNA virus infections.
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| Miyahira AK, Shahangian A, Hwang S, Sun R, Cheng G.
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| J Immunol 182(4):2248-57.
2009
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| 34 | IRF3
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| Inhibition of the IFN-beta response in hepatocellular carcinoma by alternative spliced isoform of IFN regulatory factor-3.
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| Marozin S, Altomonte J, Stadler F, Thasler WE, Schmid RM, Ebert O.
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| Mol Ther 16(11):1789-97. Epub 2008 Sep 9.
2008
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| 35 | IRF3
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| Mechanisms of activation of interferon regulator factor 3: the role of C-terminal domain phosphorylation in IRF-3 dimerization and DNA binding.
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| Dragan AI, Hargreaves VV, Makeyeva EN, Privalov PL.
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| Nucleic Acids Res 35(11):3525-34. Epub 2007 May 5. 2007
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| 36 | NCOA2, IRF3
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| The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression.
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| Reily MM, Pantoja C, Hu X, Chinenov Y, Rogatsky I.
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| EMBO J 25(1):108-17. Epub 2005 Dec 15. 2006
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| 37 | TBK1, IRF3
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| Viral targeting of the interferon-{beta}-inducing Traf family member-associated NF-{kappa}B activator (TANK)-binding kinase-1.
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| Unterstab G, Ludwig S, Anton A, Planz O, Dauber B, Krappmann D, Heins G, Ehrhardt C, Wolff T.
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| Proc Natl Acad Sci U S A 102(38):13640-5. Epub 2005 Sep 9. 2005
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| 38 | IRF7, IRF3
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| Regulation of the transcriptional activity of the IRF7 promoter by a pathway independent of interferon signaling.
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| Ning S, Huye LE, Pagano JS.
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| J Biol Chem 280(13):12262-70. Epub 2005 Jan 21. 2005
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| 39 | IRF3, PPIB
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| Role of cyclophilin B in activation of interferon regulatory factor-3.
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| Obata Y, Yamamoto K, Miyazaki M, Shimotohno K, Kohno S, Matsuyama T.
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| J Biol Chem 280(18):18355-60. Epub 2005 Mar 10.
2005
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| 40 | CREBBP, NCOA1, ETS2, TP53, IRF3, EP300
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| A Conserved alpha-helical motif mediates the binding of diverse nuclear proteins to the SRC1 interaction domain of CBP.
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| Matsuda S, Harries JC, Viskaduraki M, Troke PJ, Kindle KB, Ryan C, Heery DM.
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| J Biol Chem 279(14):14055-64. Epub 2004 Jan 13. 2004
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| 41 | ACTN4, AURKC, CKM, CYP2B6, CYTH2, DMPK, FOSB, IRF3, ITPKC, MIA, SIX5, VASP
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| The telomeric region of BTA18 containing a potential QTL region for health in cattle exhibits high similarity to the HSA19q region in humans small star, filled
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| Brunner RM, Sanftleben H, Goldammer T, Kuhn C, Weikard R, Kata SR, Womack JE, Schwerin M.
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| Genomics 81(3):270-8. 2003
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| 42 | IRF3, ZNF143
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| The Small RNA gene activator protein, SphI postoctamer homology-binding factor/selenocysteine tRNA gene transcription activating factor, stimulates transcription of the human interferon regulatory factor-3 gene.
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| Mach CM, Hargrove BW, Kunkel GR.
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| J Biol Chem 277(7):4853-8. 2002
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| 43 | IRF3, TLR3, TLR4
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| IRF3 mediates a TLR3/TLR4-specific antiviral gene program.
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| Doyle S, Vaidya S, O'Connell R, Dadgostar H, Dempsey P, Wu T, Rao G, Sun R, Haberland M, Modlin R, Cheng G.
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| Immunity 17(3):251-63. 2002
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| 44 | IRF3
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| Dual utilization of an acceptor/donor splice site governs the alternative splicing of the IRF-3 gene.
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| Karpova AY, Howley PM, Ronco LV.
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| Genes Dev 14(22):2813-8. 2000
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| 45 | IRF3
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| Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription.
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| Lin R, et al.
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| Mol Cell Biol 19(2):959-66. 1999
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| 46 | IRF3
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| Structural and functional analysis of interferon regulatory factor 3: localization of the transactivation and autoinhibitory domains.
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| Lin R, et al.
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| Mol Cell Biol 19(4):2465-74. 1999
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| 47 | IRF3
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| Cloning and functional analysis of the human IRF-3 promoter.
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| Lowther WJ, Moore PA, Carter KC, Pitha PM.
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| DNA Cell Biol 18(9):685-92 1999
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| 48 | IRF3
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| Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3.
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| Juang Y, et al.
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| Proc Natl Acad Sci U S A 95(17):9837-42. 1998
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| 49 | IRF3
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| Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker.
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| Bellingham J, et al.
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| Ann Hum Genet 62 ( Pt 3):231-4. 1998
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| 50 | IRF3
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| Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1.
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| Weaver BK, et al.
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| Mol Cell Biol 18(3):1359-68. 1998
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| 51 | IRF3
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| Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.
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| Au WC, et al.
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| Proc Natl Acad Sci U S A 92(25):11657-61. 1995
|