Citations for
1IRF3, IRF5, IRF7
DNA-binding landscape of IRF3, IRF5 and IRF7 dimers: implications for dimer-specific gene regulation.
Andrilenas KK, Ramlall V, Kurland J, Leung B, Harbaugh AG, Siggers T.
Nucleic Acids Res ucleic Acids Res. 2018 Jan 18. doi: 10.1093/nar/gky002. [Epub ahead of print] 2018
2ANKRD1, IRF3
Ankyrin repeat domain 1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum.
Bin L, Li X, Richers B, Streib JE, Hu JW, Taylor P, Leung DYM.
J Allergy Clin Immunol 141(6):2085-2093.e1. doi: 10.1016/j.jaci.2018.01.001. Epub 2018 Jan 31. 2018
3IRF3, ORMDL3
Mechanisms and roles by which IRF-3 mediates the regulation of ORMDL3 transcription in respiratory syncytial virus infection.
Wang XH, Shu J, Jiang CM, Zhuang LL, Yang WX, Zhang HW, Wang LL, Li L, Chen XQ, Jin R, Zhou GP.
Int J Biochem Cell Biol 87:8-17. doi: 10.1016/j.biocel.2017.03.007. Epub 2017 Mar 20. 2017
4IRF3, SNRNP200, TBK1
Spliceosome SNRNP200 Promotes Viral RNA Sensing and IRF3 Activation of Antiviral Response.
Tremblay N, Baril M, Chatel-Chaix L, Es-Saad S, Park AY, Koenekoop RK, Lamarre D.
PLoS Pathog 12(7):e1005772. doi: 10.1371/journal.ppat.1005772. eCollection 2016 Jul. Erratum in: PLoS Pathog. 2017 Jan 24;13(1):e1006174. 2016
5HAVCR2, IRF3, TLR4
Tim-3 promotes intestinal homeostasis in DSS colitis by inhibiting M1 polarization of macrophages.
Jiang X, Yu J, Shi Q, Xiao Y, Wang W, Chen G, Zhao Z, Wang R, Xiao H, Hou C, Feng J, Ma Y, Shen B, Wang L, Li Y, Han G.
Clin Immunol 160(2):328-35. doi: 10.1016/j.clim.2015.07.008. Epub 2015 Jul 21. 2015
6DDX58, EFTUD2, IFIH1, IRF3
EFTUD2 Is a Novel Innate Immune Regulator Restricting Hepatitis C Virus Infection through the RIG-I/MDA5 Pathway.
Zhu C, Xiao F, Hong J, Wang K, Liu X, Cai D, Fusco DN, Zhao L, Jeong SW, Brisac C, Chusri P, Schaefer EA, Zhao H, Peng LF, Lin W, Chung RT.
J Virol 89(13):6608-18. doi: 10.1128/JVI.00364-15. Epub 2015 Apr 15. 2015
7IRF3, TBK1, TMEM173
Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-κB activation through TBK1.
Abe T, Barber GN.
J Virol 88(10):5328-41. doi: 10.1128/JVI.00037-14. Epub 2014 Mar 5. 2014
8FOXO1, IRF3
FoxO1 negatively regulates cellular antiviral response by promoting degradation of IRF3.
Lei CQ, Zhang Y, Xia T, Jiang LQ, Zhong B, Shu HB.
J Biol Chem 288(18):12596-604. doi: 10.1074/jbc.M112.444794. Epub 2013 Mar 26. 2013
9DDX3X, IKBKE, IRF3
Human DEAD box helicase 3 couples IκB kinase ε to interferon regulatory factor 3 activation.
Gu L, Fullam A, Brennan R, Schröder M.
Mol Cell Biol 33(10):2004-15. doi: 10.1128/MCB.01603-12. Epub 2013 Mar 11. 2013
10IRF3, TBK1, TMEM173, ULK1
Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling.
Konno H, Konno K, Barber GN.
Cell 155(3):688-98. doi: 10.1016/j.cell.2013.09.049. Epub 2013 Oct 10. 2013
11IRF3, OPTN
Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells.
Munitic I, Giardino Torchia ML, Meena NP, Zhu G, Li CC, Ashwell JD.
J Immunol 191(12):6231-40. doi: 10.4049/jimmunol.1301696. Epub 2013 Nov 15. 2013
12CGAS, IRF3, TMEM173
Structural and functional analyses of DNA-sensing and immune activation by human cGAS.
Kato K, Ishii R, Goto E, Ishitani R, Tokunaga F, Nureki O.
PLoS One 8(10):e76983. doi: 10.1371/journal.pone.0076983. eCollection 2013. 2013
13IRF3, SP1
Characterization of a spliced variant of human IRF-3 promoter and its regulation by the transcription factor Sp1.
Ren W, Zhu LH, Xu HG, Jin R, Zhou GP.
Mol Biol Rep 39(6):6987-93. Epub 2012 Feb 4. 2012
14IRF3, SP1, SP3
Transcription factors Sp1 and Sp3 regulate basal transcription of the human IRF-3 gene.
Xu HG, Jin R, Ren W, Zou L, Wang Y, Zhou GP.
Biochimie 94(6):1390-7. doi: 10.1016/j.biochi.2012.03.011. Epub 2012 Mar 17. 2012
15E2F1, IRF3
Direct repression of the human IRF-3 promoter by E2F1.
Xu HG, Ren W, Zou L, Wang Y, Jin R, Zhou GP.
Immunogenetics 63(4):189-96. Epub 2011 Jan 12. 2011
16IRF3, IRF8
IRF8 and IRF3 cooperatively regulate rapid interferon-β induction in human blood monocytes.
Li P, Wong JJ, Sum C, Sin WX, Ng KQ, Koh MB, Chin KC.
Blood 117(10):2847-54. Epub 2011 Jan 12. 2011
17CASP8, DDX58, IRF3, RIPK1
RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein.
Rajput A, Kovalenko A, Bogdanov K, Yang SH, Kang TB, Kim JC, Du J, Wallach D.
Immunity 34(3):340-51. 2011
18IRF3
Identification of novel alternative splicing variants of interferon regulatory factor 3.
Li Y, Hu X, Song Y, Lu Z, Ning T, Cai H, Ke Y.
Biochim Biophys Acta 1809(3):166-75. Epub 2011 Jan 28. 2011
19CASP8, IRF3
Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradation.
Sears N, Sen GC, Stark GR, Chattopadhyay S.
J Biol Chem 286(38):33037-44. Epub 2011 Aug 4. 2011
20HERC5, IRF3, ISG15
Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification.
Shi HX, Yang K, Liu X, Liu XY, Wei B, Shan YF, Zhu LH, Wang C.
Mol Cell Biol 30(10):2424-36. Epub 2010 Mar 22.PMID: 20308324 2010
21IRF3
Pathogen specific, IRF3-dependent signaling and innate resistance to human kidney infection.
Fischer H, Lutay N, Ragnarsdóttir B, Yadav M, Jönsson K, Urbano A, Al Hadad A, Rämisch S, Storm P, Dobrindt U, Salvador E, Karpman D, Jodal U, Svanborg C.
PLoS Pathog 6(9):e1001109. 2010
22IRF3
Identification of a novel in vivo virus-targeted phosphorylation site in interferon regulatory factor-3 (IRF3).
Bergstroem B, Johnsen IB, Nguyen TT, Hagen L, Slupphaug G, Thommesen L, Anthonsen MW.
J Biol Chem 285(32):24904-14. Epub 2010 May 28. 2010
23IRF3
Viral apoptosis is induced by IRF-3-mediated activation of Bax.
Chattopadhyay S, Marques JT, Yamashita M, Peters KL, Smith K, Desai A, Williams BR, Sen GC.
EMBO J 29(10):1762-73. Epub 2010 Apr 1. 2010
24IRF3
Aberrant expression of interferon regulatory factor 3 in human lung cancer.
Tokunaga T, Naruke Y, Shigematsu S, Kohno T, Yasui K, Ma Y, Chua KJ, Katayama I, Nakamura T, Hishikawa Y, Koji T, Yatabe Y, Nagayasu T, Fujita T, Matsuyama T, Hayashi H.
Biochem Biophys Res Commun 397(2):202-7. Epub 2010 May 23. 2010
25IRF3
Characterization of the human IRF-3 promoter and its regulation by the transcription factor E2F1.
Xu HG, Ren W, Lu C, Zhou GP.
Mol Biol Rep 37(7):3073-80. Epub 2009 Oct 14. 2010
26IRF3, MAVS, TRAF5
TRAF5 is a downstream target of MAVS in antiviral innate immune signaling.
Tang ED, Wang CY.
PLoS One 5(2):e9172. doi: 10.1371/journal.pone.0009172. 2010
27IRF3
The TAK1-JNK cascade is required for IRF3 function in the innate immune response.
Zhang B, Li M, Chen L, Yang K, Shan Y, Zhu L, Sun S, Li L, Wang C.
Cell Res 19(4):412-28. 2009
28IRF3, TBK1
TANK-binding kinase-1 plays an important role during in vitro and in vivo type I IFN responses to DNA virus infections.
Miyahira AK, Shahangian A, Hwang S, Sun R, Cheng G.
J Immunol 182(4):2248-57. 2009
29IRF3
Inhibition of the IFN-beta response in hepatocellular carcinoma by alternative spliced isoform of IFN regulatory factor-3.
Marozin S, Altomonte J, Stadler F, Thasler WE, Schmid RM, Ebert O.
Mol Ther 16(11):1789-97. Epub 2008 Sep 9. 2008
30IRF3
Mechanisms of activation of interferon regulator factor 3: the role of C-terminal domain phosphorylation in IRF-3 dimerization and DNA binding.
Dragan AI, Hargreaves VV, Makeyeva EN, Privalov PL.
Nucleic Acids Res 35(11):3525-34. Epub 2007 May 5. 2007
31NCOA2, IRF3
The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression.
Reily MM, Pantoja C, Hu X, Chinenov Y, Rogatsky I.
EMBO J 25(1):108-17. Epub 2005 Dec 15. 2006
32TBK1, IRF3
Viral targeting of the interferon-{beta}-inducing Traf family member-associated NF-{kappa}B activator (TANK)-binding kinase-1.
Unterstab G, Ludwig S, Anton A, Planz O, Dauber B, Krappmann D, Heins G, Ehrhardt C, Wolff T.
Proc Natl Acad Sci U S A 102(38):13640-5. Epub 2005 Sep 9. 2005
33IRF7, IRF3
Regulation of the transcriptional activity of the IRF7 promoter by a pathway independent of interferon signaling.
Ning S, Huye LE, Pagano JS.
J Biol Chem 280(13):12262-70. Epub 2005 Jan 21. 2005
34IRF3, PPIB
Role of cyclophilin B in activation of interferon regulatory factor-3.
Obata Y, Yamamoto K, Miyazaki M, Shimotohno K, Kohno S, Matsuyama T.
J Biol Chem 280(18):18355-60. Epub 2005 Mar 10. 2005
35CREBBP, NCOA1, ETS2, TP53, IRF3, EP300
A Conserved alpha-helical motif mediates the binding of diverse nuclear proteins to the SRC1 interaction domain of CBP.
Matsuda S, Harries JC, Viskaduraki M, Troke PJ, Kindle KB, Ryan C, Heery DM.
J Biol Chem 279(14):14055-64. Epub 2004 Jan 13. 2004
36ACTN4, AURKC, CKM, CYP2B6, CYTH2, DMPK, FOSB, IRF3, ITPKC, MIA, SIX5, VASP
The telomeric region of BTA18 containing a potential QTL region for health in cattle exhibits high similarity to the HSA19q region in humans small star, filled
Brunner RM, Sanftleben H, Goldammer T, Kuhn C, Weikard R, Kata SR, Womack JE, Schwerin M.
Genomics 81(3):270-8. 2003
37IRF3, ZNF143
The Small RNA gene activator protein, SphI postoctamer homology-binding factor/selenocysteine tRNA gene transcription activating factor, stimulates transcription of the human interferon regulatory factor-3 gene.
Mach CM, Hargrove BW, Kunkel GR.
J Biol Chem 277(7):4853-8. 2002
38IRF3, TLR3, TLR4
IRF3 mediates a TLR3/TLR4-specific antiviral gene program.
Doyle S, Vaidya S, O'Connell R, Dadgostar H, Dempsey P, Wu T, Rao G, Sun R, Haberland M, Modlin R, Cheng G.
Immunity 17(3):251-63. 2002
39IRF3
Dual utilization of an acceptor/donor splice site governs the alternative splicing of the IRF-3 gene.
Karpova AY, Howley PM, Ronco LV.
Genes Dev 14(22):2813-8. 2000
40IRF3
Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription.
Lin R, et al.
Mol Cell Biol 19(2):959-66. 1999
41IRF3
Structural and functional analysis of interferon regulatory factor 3: localization of the transactivation and autoinhibitory domains.
Lin R, et al.
Mol Cell Biol 19(4):2465-74. 1999
42IRF3
Cloning and functional analysis of the human IRF-3 promoter.
Lowther WJ, Moore PA, Carter KC, Pitha PM.
DNA Cell Biol 18(9):685-92 1999
43IRF3
Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3.
Juang Y, et al.
Proc Natl Acad Sci U S A 95(17):9837-42. 1998
44IRF3
Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker.
Bellingham J, et al.
Ann Hum Genet 62 ( Pt 3):231-4. 1998
45IRF3
Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1.
Weaver BK, et al.
Mol Cell Biol 18(3):1359-68. 1998
46IRF3
Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.
Au WC, et al.
Proc Natl Acad Sci U S A 92(25):11657-61. 1995