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FLASH GENE

Symbol

FHL3

contributors: npt/mct - updated : 20-10-2012

HGNC name	four and a half LIM domains 3
HGNC id	3704

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004468 6 - 1662 NP_004459 31 280 - 2007 17389685 NM_001243878 5 - 1486 NP_001230807 - 172 - 2007 17389685

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   predominantly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four cysteine-rich LIM/double finger motifs, and the second zinc finger motif in LIM4 was responsible for the auto-activation of FHL3
	a half LIM, extra finger domain

HOMOLOGY

interspecies	homolog to murine Fhl3 and Fhl2
	homolog to Drosophila cg9959
	homolog to C.elegans f25h5.1a

intraspecies

homolog to fhl2

Homologene

FAMILY

four and a half LIM domain family of LIM protein

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	FHL3 association with MYOD1 may contribute to the regulation of MYOD-dependent transcription of muscle genes and thereby myogenesis
	significant regulator of actin cytoskeletal dynamics in skeletal myoblasts
	SOX15, FHL3 and FOXK1 function to coordinately regulate the myogenic progenitor cell population and skeletal muscle regeneration
	regulates transactivation by a novel molecular mechanism, not through binding to HIF1A or EP300

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	muscle development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	MYOD1-associated protein (functioning as its potent negative co-transcriptional regulator)
	bound MZF1 (negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF1)
	FHL1, FHL2, and FHL3 physically and functionally interact with SMAD2, SMAD3, and SMAD4, important regulators of cancer development and progression, in a TGF-beta-independent manner
	is a novel ANG binding partner (this interaction may provide some clues to the mechanisms of ANG-regulated cell growth and apoptosis)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS