Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

BTRC

contributors: mct - updated : 24-04-2018

HGNC name	beta-transducin repeat containing
HGNC id	1144

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function of BTRC results in accumulation of MDM2 and decreased TP53 activity, and resistance to apoptosis induced by DNA damaging agents tumoral     --low   suppresses prostate cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate combining BTRC inhibition with androgen ablation could benefit advanced prostate cancer patients

ANIMAL & CELL MODELS