| 1 | BTRC, PLK4, TIAM1
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| The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels
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| Porter AP, Reed H, White GRM, Ogg EL, Whalley HJ, Malliri A.
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| J Cell Sci. Apr 1;134(7):jcs252502. doi: 10.1242/jcs.252502. Epub 2021 Apr 13. 2021
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| 2 | BTRC, FBXW11, MAP3K5
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| β-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress.
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| Cheng R, Takeda K, Naguro I, Hatta T, Iemura SI, Natsume T, Ichijo H, Hattori K.
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| Biochim Biophys Acta Gen Subj 1862(10):2271-2280. doi: 10.1016/j.bbagen.2018.07.015. Epub 2018 Jul 18.
2018
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| 3 | BTRC, USP33
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| Deubiquitinase USP33 is negatively regulated by β-TrCP through ubiquitin-dependent proteolysis.
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| Cheng Q, Yuan Y, Li L, Guo T, Miao Y, Ren Y, Liu J, Feng Q, Wang X, Zhao P, Zuo Y, Qian L, Zhang L, Zheng H.
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| Exp Cell Res 356(1):1-7. doi: 10.1016/j.yexcr.2017.05.011. Epub 2017 May 13.
2017
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| 4 | BTRC, DMRT1, FBXW11
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| Regulation of mitosis-meiosis transition by the ubiquitin ligase β-TrCP in male germ cells.
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| Nakagawa T, Zhang T, Kushi R, Nakano S, Endo T, Nakagawa M, Yanagihara N, Zarkower D, Nakayama K.
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| Development 144(22):4137-4147. doi: 10.1242/dev.158485. Epub 2017 Oct 5.
2017
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| 5 | BTRC, CREB3L3
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| β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H.
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| Cheng Y, Gao WW, Tang HM, Deng JJ, Wong CM, Chan CP, Jin DY.
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| Sci Rep 6:23938. doi: 10.1038/srep23938.
2016
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| 6 | BTRC, FBXL14, FBXL5, FBXO11, FBXO45, FBXW7
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| F-box proteins: Keeping the epithelial-to-mesenchymal transition (EMT) in check.
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| Díaz VM, de Herreros AG.
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| Semin Cancer Biol 36:71-9. doi: 10.1016/j.semcancer.2015.10.003. Epub 2015 Nov 11. Review.
2016
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| 7 | BTRC, EIF2S1, PPP1R15B
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| DNA Damage Regulates Translation through β-TRCP Targeting of CReP.
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| Loveless TB, Topacio BR, Vashisht AA, Galaang S, Ulrich KM, Young BD, Wohlschlegel JA, Toczyski DP.
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| PLoS Genet 11(6):e1005292. doi: 10.1371/journal.pgen.1005292. eCollection 2015 Jun.
2015
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| 8 | BTRC, COP1, SMURF1, TRIB2
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| TRIB2 inhibits Wnt/β-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, β-TrCP, COP1 and Smurf1, in liver cancer cells.
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| Xu S, Tong M, Huang J, Zhang Y, Qiao Y, Weng W, Liu W, Wang J, Sun F.
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| FEBS Lett 588(23):4334-41. doi: 10.1016/j.febslet.2014.09.042. Epub 2014 Oct 13. 2014
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| 9 | BHLHE40, BTRC
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| USP17- and SCFβTrCP--regulated degradation of DEC1 controls the DNA damage response.
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| Kim J, D'Annibale S, Magliozzi R, Low TY, Jansen P, Shaltiel IA, Mohammed S, Heck AJ, Medema RH, Guardavaccaro D.
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| Mol Cell Biol 34(22):4177-85. doi: 10.1128/MCB.00530-14. Epub 2014 Sep 8.
2014
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| 10 | BTRC, TFAP4
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| Proteasome-dependent degradation of transcription factor activating enhancer-binding protein 4 (TFAP4) controls mitotic division.
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| D'Annibale S, Kim J, Magliozzi R, Low TY, Mohammed S, Heck AJ, Guardavaccaro D.
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| J Biol Chem 289(11):7730-7. doi: 10.1074/jbc.M114.549535. Epub 2014 Feb 5.
2014
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| 11 | BTRC, OIP5
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| βTrCP-mediated ubiquitylation regulates protein stability of Mis18β in a cell cycle-dependent manner.
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| Kim IS, Lee M, Park JH, Jeon R, Baek SH, Kim KI.
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| Biochem Biophys Res Commun 443(1):62-7. doi: 10.1016/j.bbrc.2013.11.058. Epub 2013 Nov 21.
2014
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| 12 | BTRC, GHR
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| βTrCP interacts with the ubiquitin-dependent endocytosis motif of the GH receptor in an unconventional manner.
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| da Silva Almeida AC, Hocking HG, Boelens R, Strous GJ, van Rossum AG.
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| Biochem J 453(2):291-301. doi: 10.1042/BJ20121843.
2013
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| 13 | BTRC, TERF1
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| The F-box protein β-TrCP promotes ubiquitination of TRF1 and regulates the ALT-associated PML bodies formation in U2OS cells.
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| Wang C, Xiao H, Ma J, Zhu Y, Yu J, Sun L, Sun H, Liu Y, Jin C, Huang H.
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| Biochem Biophys Res Commun 434(4):728-34. doi: 10.1016/j.bbrc.2013.03.096. Epub 2013 Apr 10.
2013
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| 14 | BTRC, GHR
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| βTrCP controls GH receptor degradation via two different motifs.
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| da Silva Almeida AC, Strous GJ, van Rossum AG.
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| Mol Endocrinol 26(1):165-77. doi: 10.1210/me.2011-1211. Epub 2011 Oct 27.
2012
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| 15 | BTRC, DEPTOR
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| DEPTOR ubiquitination and destruction by SCF(β-TrCP).
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| Wang Z, Zhong J, Gao D, Inuzuka H, Liu P, Wei W.
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| Am J Physiol Endocrinol Metab 303(2):E163-9. doi: 10.1152/ajpendo.00105.2012. Epub 2012 Mar 27. Review.
2012
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| 16 | BTRC, CTTN
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| Extracellular signal-regulated kinase (ERK) regulates cortactin ubiquitination and degradation in lung epithelial cells.
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| Zhao J, Wei J, Mialki R, Zou C, Mallampalli RK, Zhao Y.
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| J Biol Chem 287(23):19105-14. doi: 10.1074/jbc.M112.339507. Epub 2012 Apr 18.
2012
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| 17 | BTRC, PHLPP1
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| Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.
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| Warfel NA, Niederst M, Stevens MW, Brennan PM, Frame MC, Newton AC.
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| J Biol Chem 286(22):19777-88. Epub 2011 Mar 28.
2011
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| 18 | BMI1, BTRC
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| βTrCP regulates BMI1 protein turnover via ubiquitination and degradation.
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| Sahasrabuddhe AA, Dimri M, Bommi PV, Dimri GP.
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| Cell Cycle 10(8):1322-30. Epub 2011 Apr 15.
2011
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| 19 | BTRC, FBXW11
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| Role of β-TrCP ubiquitin ligase receptor in UVB mediated responses in skin.
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| Bhatia N, Demmer TA, Sharma AK, Elcheva I, Spiegelman VS.
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| Arch Biochem Biophys 508(2):178-84. Epub 2010 Dec 25.
2011
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| 20 | BTRC, FBXW11
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| Specificity, location and function of βTrCP isoforms and their splice variants.
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| Putters J, Slotman JA, Gerlach JP, Strous GJ.
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| Cell Signal 23(4):641-7. Epub 2010 Dec 5.
2011
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| 21 | BTRC, NRF1, SYVN1
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| Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms.
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| Tsuchiya Y, Morita T, Kim M, Iemura S, Natsume T, Yamamoto M, Kobayashi A.
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| Mol Cell Biol 31(22):4500-12. doi: 10.1128/MCB.05663-11. Epub 2011 Sep 12. 2011
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| 22 | BTRC, GHR
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| SCF(TrCP) acts in endosomal sorting of the GH receptor.
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| van Kerkhof P, Westgeest M, Hassink G, Strous GJ.
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| Exp Cell Res 317(7):1071-82. doi: 10.1016/j.yexcr.2010.12.020. Epub 2010 Dec 30.
2011
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| 23 | BTRC, FBXW11, USP47
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| The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival.
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| Peschiaroli A, Skaar JR, Pagano M, Melino G.
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| Oncogene 29(9):1384-93. Epub 2009 Dec 7.
2010
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| 24 | BTRC, CSNK1A1
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| Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.
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| Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, Wan L, Ang XL, Mock C, Yin H, Stommel JM, Gygi S, Lahav G, Asara J, Xiao ZX, Kaelin WG Jr, Harper JW, Wei W.
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| Cancer Cell 18(2):147-59.
2010
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| 25 | BTRC, FOXO3
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| Inhibition of FOXO3 tumor suppressor function by betaTrCP1 through ubiquitin-mediated degradation in a tumor mouse model.
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| Tsai WB, Chung YM, Zou Y, Park SH, Xu Z, Nakayama K, Lin SH, Hu MC.
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| PLoS One 5(7):e11171.
2010
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| 26 | BTRC
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| beta-TrCP inhibition reduces prostate cancer cell growth via upregulation of the aryl hydrocarbon receptor.
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| Gluschnaider U, Hidas G, Cojocaru G, Yutkin V, Ben-Neriah Y, Pikarsky E.
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| PLoS One 5(2):e9060.
2010
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| 27 | BTRC, PHLPP1
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| beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt.
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| Li X, Liu J, Gao T.
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| Mol Cell Biol 29(23):6192-205. Epub 2009 Sep 21.
2009
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| 28 | BTRC
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| Abnormal retinal development in the Btrc null mouse.
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| Baguma-Nibasheka M, Kablar B.
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| Dev Dyn 238(10):2680-7.
2009
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| 29 | PLK1, BTRC, BORA
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| Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression.
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| Seki A, Coppinger JA, Du H, Jang CY, Yates JR 3rd, Fang G.
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| J Cell Biol 181(1):65-78. Epub 2008 Mar 31. 2008
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| 30 | BTRC, FBXW11
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| The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2.
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| Ohsaki K, Oishi K, Kozono Y, Nakayama K, Nakayama KI, Ishida N.
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| J Biochem 144(5):609-18. Epub 2008 Sep 8.
2008
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| 31 | BTRC, FBXW11
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| Silencing of both beta-TrCP1 and HOS (beta-TrCP2) is required to suppress human immunodeficiency virus type 1 Vpu-mediated CD4 down-modulation.
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| Butticaz C, Michielin O, Wyniger J, Telenti A, Rothenberger S.
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| J Virol 81(3):1502-5. Epub 2006 Nov 22.
2007
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| 32 | BTRC, FBXW11
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| SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection.
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| Tan M, Gallegos JR, Gu Q, Huang Y, Li J, Jin Y, Lu H, Sun Y.
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| Neoplasia 8(12):1042-54.
2006
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| 33 | BTRC, CREBBP, CSRP2, FKBP8, GAS1, GSK3B, HHAT, HHIP, IFT88, KIF27, KIF3A, KIF7, RAB23, SHH, STIL, STK36, SUFU, VTN
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| Hedgehog signaling and congenital malformations.
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| Nieuwenhuis E, Hui CC.
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| Clin Genet 67(3):193-208. 2005
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| 34 | CSNK1E, CNSK1G2, PER1, CLOCK, BTRC
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| SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.
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| Shirogane T, Jin J, Ang XL, Harper JW.
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| J Biol Chem 280(29):26863-72. Epub 2005 May 24. 2005
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| 35 | APC, BTRC, CTNNB1
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| APC/CTNNB1 (beta-catenin) pathway alterations in human prostate cancers.
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| Gerstein AV, Almeida TA, Zhao G, Chess E, Shih IeM, Buhler K, Pienta K, Rubin MA, Vessella R, Papadopoulos N.
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| Genes Chromosomes Cancer 34(1):9-16. 2002
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| 36 | BTRC, FBXW11
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| Expression profiles of betaTRCP1 and betaTRCP2, and mutation analysis of betaTRCP2 in gastric cancer.
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| Saitoh T, Katoh M.
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| Int J Oncol 18(5):959-64. 2001
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| 37 | BTRC, FBXL3, FBXO3, FBXO4, FBXO5, FBXO6, FBXO9, FBXW2
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| Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors.
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| Chiaur DS, Murthy S, Cenciarelli C, Parks W, Loda M, Inghirami G, Demetrick D, Pagano M.
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| Cytogenet Cell Genet 88(3-4):255-8. 2000
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| 38 | BTRC
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| The BTRC gene, encoding a human F-Box/WD40-repeat protein, maps to chromosome 10q24-q25.
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| Fujiwara T, et al.
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| Genomics 58(1):104-5. No abstract available 1999
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| 39 | BTRC, FBXL2, FBXO16, FBXW5, FBXL3, FBXL21, FBXL4, FBXL5, FBXL6, FBXL7, LRRC29, FBXO10, FBXO11, LMO7, FBXO21, FBXO22, FBXO24, FBXO25, FBXO3, FBXO4, FBXO5, FBXO6, FBXO7, FBXO8, FBXO9, FBXW11, SHFM3P1, FBXW8
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| Identification of a family of human F-box proteins.
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| Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M.
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| Curr Biol 9(20):1177-9. 1999
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| 40 | BTRC
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| Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP.
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| Spencer E, Jiang J, Chen ZJ.
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| Genes Dev 13(3):284-94. 1999
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| 41 | BTRC
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| A complex containing betaTrCP recruits Cdc34 to catalyse ubiquitination of IkappaBalpha.
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| Vuillard L, Nicholson J, Hay RT.
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| FEBS Lett 455(3):311-4. 1999
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| 42 | BTRC
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| A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif.
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| Margottin F, et al.
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| Mol Cell 1(4):565-74. 1998
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| 43 | BTRC
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| Identification of the receptor component of the IkappaBalpha-ubiquitin ligase.
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| Yaron A, Hatzubai A, Davis M, Lavon I, Amit S, Manning AM, Andersen JS, Mann M, Mercurio F, Ben-Neriah Y.
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| Nature 396(6711):590-4. 1998
|