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FLASH GENE

Symbol

WEE1

contributors: mct/ - updated : 02-07-2016

HGNC name	WEE1 homolog (S. pombe)
HGNC id	12761

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in hepatocellular carcinoma constitutional     --over   in rheumatoid cells inducing aberrant mitosis constitutional     --over   with PKMYT1 induced the phosphorylation of CDC2 leading to G2/M arrest constitutional     --low   caused a block in DNA replication, resulting in accumulation of cells in S phase

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     combination of WEE1 inhibitor and TNFSF10 could provide a novel combination for the treatment of basal/triple-negative breast cancer cancer brain glioma/neuroblstoma inhibition of WEE1 kinase holds potential as a therapeutic approach in treatment of glioblastoma

ANIMAL & CELL MODELS