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FLASH GENE
Symbol FGF17 contributors: mct - updated : 11-10-2022
HGNC name fibroblast growth factor 17
HGNC id 3673
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • heparin-binding growth factors family
  • FGF8 subfamily
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in the induction and patterning of the embryonic brain
  • FGF8, FGF17 and EMX2 play distinct roles in the molecular regionalization of frontal cortex subdivisions (
  • plays important roles in both the anatomical and functional development of the auditory midbrain
  • with FGF8, is a key factor in the patterning of the mid-hindbrain region with a complex picture of spatiotemporal gene expression during the various stages of cerebellar development
  • FGFR2 and FGF17 are involved in the development of frontal brain regions and impairments in cognitive and social behaviors, respectively
  • FGF8, FGF17 and FGF18 are required for closure of the embryonic ventral body wall
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • plasma membrane binding of FGF8, and most likely of the FGF8 family members FGF17 and FGF18, to CUBN improves Fgf ligand endocytosis and availability to FgfRs, thus modulating Fgf signaling activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HH20
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in benign prostatic hyperplasia and in prostate carcinoma
    Susceptibility to congenital Hypogonadotropic Hypogonadism
    Variant & Polymorphism
    Candidate gene
    Marker
  • FGF10 and FGF17 could be prognostic biomarkers for survivals of acute myeloid leukemia patients
  • Therapy target
    ANIMAL & CELL MODELS