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FLASH GENE
Symbol SOX13 contributors: mct/npt - updated : 17-05-2010
HGNC name SRY (sex determining region Y)-box 13
HGNC id 11192
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal leucine-zipper Q domain
  • a central high mobility group (HMG) box DNA-binding domain
  • a neighboring glutamine stretch (D subfamily)
    • HOMOLOGY
    interspecies homolog to rattus Sox13 (89 pc)
    homolog to murine Sox13 (90.4 pc)
    homolog to Drosophila Sox102F (75 pc)
    Homologene
    FAMILY
  • SRY-related HMG box family of transcription factors
  • SoxD transcription factor family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as a modulator of LINE retroposons promoter
  • involved in the regulation of embryonic development and in the determination of cell fate
  • exhibits a distinct spatial and temporal expression pattern during chondrogenesis, neurogenesis, and limb development (Wang 2006)
  • repress Wnt/TCF signaling by interacting with HNF1A (Marfil 2010)
  • modulates T cell specification and is an autoimmune antigen (Lefebvre 2010)
  • enhance transactivation by SOX9 in chondrocytes, but antagonize SOX9 and other SoxE proteins in oligodendrocytes and melanocytes, and also repress transcription through various mechanisms in several other lineages (Lefebvre 2010)
  • may have a function in signaling by the developmentally important Wnt/T cell factor (TCF) pathway (Melichar 2007)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the sequence 5'-AACAAT-3'
    RNA
    small molecule
    protein
  • interaction between HHEX (hematopoietically expressed homeobox) and SOX13 that modulates Wnt/TCF pathway activity (this interaction may contribute to control Wnt/TCF signaling in the early embryo) (Marfil 2010)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS