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FLASH GENE
Symbol SOX13 contributors: mct/npt - updated : 17-05-2010
HGNC name SRY (sex determining region Y)-box 13
HGNC id 11192
DNA
TYPE functioning gene
STRUCTURE 54.62 kb     14 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
text putative long or short forms (Argentaro 2001)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 4088 - 622 - Marfil (2010)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
 vessels    
Digestiveesophagus   highly
 mouth   highly
Nervousnerve   highly
Reproductivefemale systemuterus  highly
 male systemtestis  highly
Respiratoryrespiratory tracttrachea  highly
 respiratory tractlarynx  highly
Skin/Tegumentskin   predominantly
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text
  • highly, in kidney, placenta
  • expressed in the developing central nervous system including the neural tube and the developing brain
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal leucine-zipper Q domain
  • a central high mobility group (HMG) box DNA-binding domain
  • a neighboring glutamine stretch (D subfamily)
  • HOMOLOGY
    interspecies homolog to rattus Sox13 (89 pc)
    homolog to murine Sox13 (90.4 pc)
    homolog to Drosophila Sox102F (75 pc)
    Homologene
    FAMILY
  • SRY-related HMG box family of transcription factors
  • SoxD transcription factor family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as a modulator of LINE retroposons promoter
  • involved in the regulation of embryonic development and in the determination of cell fate
  • exhibits a distinct spatial and temporal expression pattern during chondrogenesis, neurogenesis, and limb development (Wang 2006)
  • repress Wnt/TCF signaling by interacting with HNF1A (Marfil 2010)
  • modulates T cell specification and is an autoimmune antigen (Lefebvre 2010)
  • enhance transactivation by SOX9 in chondrocytes, but antagonize SOX9 and other SoxE proteins in oligodendrocytes and melanocytes, and also repress transcription through various mechanisms in several other lineages (Lefebvre 2010)
  • may have a function in signaling by the developmentally important Wnt/T cell factor (TCF) pathway (Melichar 2007)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the sequence 5'-AACAAT-3'
    RNA
    small molecule
    protein
  • interaction between HHEX (hematopoietically expressed homeobox) and SOX13 that modulates Wnt/TCF pathway activity (this interaction may contribute to control Wnt/TCF signaling in the early embryo) (Marfil 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS