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FLASH GENE
Symbol CDC42BPB contributors: npt/mct - updated : 24/10/2008
HGNC name CDC42 binding protein kinase beta (DMPK-like)
HGNC id 1738
Location 14q32.3      Physical location : 103.398.715 - 103.523.742
Synonym name
  • CDC42-binding protein kinase beta
  • myotonic dystrophy kinase-related CDC42-binding kinase beta
  • serine/threonine-protein kinase MRCK beta
  • DMPK-like beta
  • Synonym symbol(s) MRCKB, KIAA1124
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 125.02 kb     37 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D14S1134E - CDC42BPB - D14S1227 - qter
    Authors Moncrieff (99)
    Physical map
    RAGE 14q32 renal tumor antigen C14orf131 14q32.33 chromosome 14 open reading frame 131 CINP 14q32.33 cyclin-dependent kinase 2-interacting protein KIAA0329 14q32-.11 cyclin-dependent kinase 2-interacting protein ANKRD9 14q32.33 ankyrin repeat domain 9 LOC283604 14q32.33 hypothetical LOC283604 RCOR 14q32.32 REST corepressor RPL23AP11 14 ribosomal protein L23a pseudogene 11 TRAF3 14q32.3 TNF receptor-associated factor 3 AMN 14q32.3 amnionless homolog (mouse) CDC42BPB 14q32.3 CDC42 binding protein kinase beta (DMPK-like) C14orf73 14 chromosome 14 open reading frame 73 TNFAIP2 14q32 tumor necrosis factor, alpha-induced protein 2 RPL21P12 14q32.33 ribosomal protein L21 pseudogene 12 RPL21P13 14 ribosomal protein L21 pseudogene 13 RPL17P4 14 ribosomal protein L17 pseudogene 4 LOC388019 14 LOC388019 EIF5 14q32.33 eukaryotic translation initiation factor 5 LAMR1P5 14 laminin receptor 1 pseudogene 5 MARK3 14q32.3 MAP/microtubule affinity-regulating kinase 3 RPL10AP1 14 ribosomal protein L10a pseudogene 1 CKB 14q32.32 creatine kinase, brain FLJ40452 14q32.33 hypothetical protein FLJ40452
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    37 - 6701 194 1711 - Olsen (2006)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Endocrinepancreas    
    Reproductivefemale systemuteruscervix  
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • from the N terminus, a serine/threonine kinase domain
  • a cysteine rich motif ressembling those of protein kinase C
  • a pleckstrin homology (PH)
  • a C1 domain with homology to that of the diacylglycerol/phorbol ester-responsive C1 domains reported to bind phorbol ester
  • a C terminal Cdc42 Roc binding domains
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • AGC Ser/Thr protein kinase family
  • dystrophia myotonica protein kinase family
  • DMPK subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • CDC42-binding protein kinase beta, phosphorylating non muscle myosin like chain (see MYLK)
  • . prerequisite for the activation of actin-myosin contractility
  • downstream effector of CDC42 in cytoskeletal reorganization
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cell polarity cytoskeletal reorganisation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS