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FLASH GENE

Symbol

BRD8

contributors: - updated : 17-09-2004

HGNC name	bromodomain containing 8
HGNC id	19874

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q31.2      Physical location : 137.475.458 - 137.514.358
Synonym name	skeletal muscle abundant protein
	thyroid hormone receptor coactivator protein
Synonym symbol(s)	SMAP, p120 , THRCP

DNA

TYPE	functioning gene
STRUCTURE	38.00 kb     29 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 3253 - 951 - Lai variant 2 - - 4074 - 1235 - Lai variant 3 - - 3086 81.3 757 - Lai

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

bromodomains,several potential sites for phosphorylation by casein kinase II and small proline-rich segments

HOMOLOGY

interspecies

ortholog to murine 2610007e11Rik

Homologene

FAMILY

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	thyroid hormone receptor coactivator protein
	ligand-regulated transcription factor
	enhancing thyroid hormone-dependent activation from thyroid

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

response elements (TREs)

INTERACTION

DNA

RNA

small molecule

protein

thyroid hormone receptor in a ligand-dependent manner

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS