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FLASH GENE

Symbol

CDIPT

contributors: - updated : 24-06-2005

HGNC name	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
HGNC id	1769

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

£LUNG AND BRAIN.

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       lowly   thymus       lowly Cardiovascular heart       lowly Digestive intestine large intestine colon   lowly   intestine small intestine     lowly   liver       highly Endocrine pancreas       lowly Nervous brain       lowly Reproductive female system ovary     lowly   male system testis     lowly   male system prostate     lowly Respiratory lung       lowly Urinary kidney       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid         Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	placenta lowly,kidney and liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to goat polledness and intersexuality gene
	homolog to Drosophila CG9245
	homolog to C.elegans Y46G5A.5

Homologene

FAMILY

member of the CDP-alcohol phosphatidyl transferase class-I family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,cytoplasm,organelle,Golgi
text	an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus

basic FUNCTION

having both phosphatidylinositol synthase and phosphatidylinositol :inositol exchange activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	phosphatidylinositol transporter

PATHWAY

metabolism

lipid/lipoprotein

signaling

phospholipid biosynthesis

a component

INTERACTION

DNA

RNA

small molecule	metal binding, cofactor,
	magnesium Mg2+,manganese Mn2+

protein

cell & other

REGULATION

inhibited by	phosphatidylinositol,phosphatidylinositol phosphate and nucleoside di- and tri- phosphates
	calcium Ca2+ and zinc Zn2+

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS