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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

MAD1L1

contributors: npt/mct/pgu - updated : 25-01-2016

HGNC name	MAD1 mitotic arrest deficient-like 1 (yeast)
HGNC id	6762

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       in lung cancer and colon cancer tumoral     --low   in lung cancer and colon cancer tumoral   LOH     in breast cancer tumoral somatic mutation       in acute leukaemia constitutional     --over   its up-regulation may promote tumors and cause resistance to current therapies

Susceptibility

to lung cancer

Variant & Polymorphism other	genetic variants in MAD1L1 confer susceptibility to lung cancer, which might result from reduced spindle checkpoint function due to attenuated function of MAD1L1

Candidate gene
Marker	reduced MAD1L1 expression is a new potential diagnostic symptom of tumor metastasis
Therapy target

ANIMAL & CELL MODELS