| basic FUNCTION
| phosphorylating a large number of important signaling proteins |
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regulating the assembly of the actin cytoskeleton |
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promoting formation of stress fibers and of focal adhesion complexes |
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playing a role in smooth muscle contraction |
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plays an important role in the process of atherosclerosis  |
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key factor in regulation of motility/invasion of breast cancer cells |
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playing a central role in the disassembly of apical junctional complex in epithelial cells |
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plays important roles in many cellular processes, including signal transduction, vesicle trafficking, and cytoskeletal organization |
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ROCK1 and ROCK2 play distinct roles in regulating keratinocyte adhesion and terminal differentiation |
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ROCK1 and ROCK2 have distinct and separate roles in adhesion complex assembly and turnover in epidermal keratinocytes |
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ROCK1, ROCK2 are necessary for acquisition of elongated and geometric cell shape, two key events for epithelial differentiation |
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ROCK1 and ROCK2, negatively regulate CD1D-mediated Ag presentation |
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ROCK2-mediated intrinsic rhythm of vascular contractility may underlie the diurnal variation of the incidence of cardiovascular diseases |
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ROCK2 is required for stabilizing actin cytoskeleton through regulating cofilin phosphorylation |
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ROCK1 and ROCK2, are involved in stress fiber assembly and cell adhesion and are assumed to be functionally redundant |
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is required for stabilizing the actin cytoskeleton and cell adhesion |
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important role for RHOA-ROCK2 signaling to maintain apico-basal polarity in retinal progenitor cells, which is essential for subsequent cellular differentiation, morphology and eventually organ function |
