| basic FUNCTION
| regulator of the stress activated protein kinase (MAPK8) |
|
regulator or key of beta cell function |
|
scaffold protein that interacts with components of the c-Jun N-terminal kinase (JNK) signal-transduction pathway  |
|
function as a scaffold protein of the JNK signaling cascade in the cytoplasm or as a transcription factor in nuclei |
|
necessary for normal axonal development and promotes axonal growth dependent upon its binding to kinesin-1 and via a newly described interaction with the ABL tyrosine kinase |
|
important regulator of axonal development and is a key target of ABL-dependent pathways that control axonal growth |
|
because it is involved in regulating cargo binding to kinesin motors, hyperphosphorylated Tau potentially can mediates impaired axonal transport in Alzheimer disease and frontotemporal dementia |
|
MAPK8IP1 and MAPK8IP2 proteins are required for normal glucose homeostasis, and can influence insulin-stimulated signal transduction mediated by IRS proteins |
|
may be acting as a scaffold protein that mediates JNK activation |
|
MAPK8IP1-mediated JNK activation plays a critical role in metabolic stress regulation of the JNK signaling pathway |
|
suppresses NOTCH1 activity |
