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FLASH GENE

Symbol

SGPL1

contributors: mct - updated : 23-05-2017

HGNC name	sphingosine-1-phosphate lyase 1
HGNC id	10817

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Sgpl1-/- mice recapitulated the main characteristics of the human disease with abnormal adrenal and renal morphology
	S1P lyase deficiency in mice causes a severe, lethal phenotype
	Sgpl1-deficient mice have low numbers of lymphocytes and high numbers of neutrophils in their blood