| 1 | SGPL1, VPS39
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| SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells.
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| Jackson J, Wischhof L, Scifo E, Pellizzer A, Wang Y, Piazzesi A, Gentile D, Siddig S, Stork M, Hopkins CE, Händler K, Weis J, Roos A, Schultze JL, Nicotera P, Ehninger D, Bano D.
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| Mol Metab. Jul;61:101503. doi: 10.1016/j.molmet.2022.101503. Epub 2022 Apr 19. 2022
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| 2 | SGPL1, SRNIA
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| Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency.
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| Lovric S, Goncalves S, Gee HY, Oskouian B, Srinivas H, Choi WI, Shril S, Ashraf S, Tan W, Rao J, Airik M, Schapiro D, Braun DA, Sadowski CE, Widmeier E, Jobst-Schwan T, Schmidt JM, Girik V, Capitani G, Suh JH, Lachaussée N, Arrondel C, Patat J, Gribouval O, Furlano M, Boyer O, Schmitt A, Vuiblet V, Hashmi S, Wilcken R, Bernier FP, Innes AM, Parboosingh JS, Lamont RE, Midgley JP, Wright N, Majewski J, Zenker M, Schaefer F, Kuss N, Greil J, Giese T, Schwarz K, Catheline V, Schanze D, Franke I, Sznajer Y, Truant AS, Adams B, Désir J, Biemann R, Pei Y, Ars E, Lloberas N, Madrid A, Dharnidharka VR, Connolly AM, Willing MC, Cooper MA, Lifton RP, Simons M, Riezman H, Antignac C, Saba JD, Hildebrandt F.
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| J Clin Invest 127(3):912-928. doi: 10.1172/JCI89626. Epub 2017 Feb 6.
2017
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| 3 | SGPL1, SRNIA
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| Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome.
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| Prasad R, Hadjidemetriou I, Maharaj A, Meimaridou E, Buonocore F, Saleem M, Hurcombe J, Bierzynska A, Barbagelata E, Bergadá I, Cassinelli H, Das U, Krone R, Hacihamdioglu B, Sari E, Yesilkaya E, Storr HL, Clemente M, Fernandez-Cancio M, Camats N, Ram N, Achermann JC, Van Veldhoven PP, Guasti L, Braslavsky D, Guran T, Metherell LA.
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| J Clin Invest 127(3):942-953. doi: 10.1172/JCI90171. Epub 2017 Feb 6.
2017
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| 4 | SGPL1, SRNIA
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| Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications.
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| Janecke AR, Xu R, Steichen-Gersdorf E, Waldegger S, Entenmann A, Giner T, Krainer I, Huber LA, Hess MW, Frishberg Y, Barash H, Tzur S, Schreyer-Shafir N, Sukenik-Halevy R, Zehavi T, Raas-Rothschild A, Mao C, Müller T.
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| Hum Mutat 38(4):365-372. doi: 10.1002/humu.23192. Epub 2017 Mar 6.
2017
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| 5 | SGPL1
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| SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production.
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| Mitroi DN, Karunakaran I, Gräler M, Saba JD, Ehninger D, Ledesma MD, van Echten-Deckert G.
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| Autophagy 13(5):885-899. doi: 10.1080/15548627.2017.1291471.
2017
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| 6 | SGPL1, SRNIA
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| Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage.
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| Vienken H, Mabrouki N, Grabau K, Claas RF, Rudowski A, Schömel N, Pfeilschifter J, Lütjohann D, van Echten-Deckert G, Meyer Zu Heringdorf D.
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| Sci Rep 7:43575. doi: 10.1038/srep43575.
2017
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| 7 | SGPL1, SRNIA
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| Genetics: SGPL1 mutations cause a novel SRNS syndrome.
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| Carney EF.
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| Nat Rev Nephrol 13(4):191. doi: 10.1038/nrneph.2017.19. Epub 2017 Feb 20. No abstract available.
2017
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| 8 | CMT2G, SGPL1
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| Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy.
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| Atkinson D, Nikodinovic Glumac J, Asselbergh B, Ermanoska B, Blocquel D, Steiner R, Estrada-Cuzcano A, Peeters K, Ooms T, De Vriendt E, Yang XL, Hornemann T, Milic Rasic V, Jordanova A.
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| Neurology 88(6):533-542. doi: 10.1212/WNL.0000000000003595. Epub 2017 Jan 11. 2017
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| 9 | SGPL1
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| Sphingosine-1-phosphate lyase is an endogenous suppressor of pulmonary fibrosis: role of S1P signalling and autophagy.
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| Huang LS, Berdyshev EV, Tran JT, Xie L, Chen J, Ebenezer DL, Mathew B, Gorshkova I, Zhang W, Reddy SP, Harijith A, Wang G, Feghali-Bostwick C, Noth I, Ma SF, Zhou T, Ma W, Garcia JG, Natarajan V.
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| Thorax 70(12):1138-48. doi: 10.1136/thoraxjnl-2014-206684. Epub 2015 Aug 18.
2015
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| 10 | SGPL1
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| Reduced Activity of Sphingosine-1-Phosphate Lyase Induces Podocyte-related Glomerular Proteinuria, Skin Irritation, and Platelet Activation.
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| Schümann J, Grevot A, Ledieu D, Wolf A, Schubart A, Piaia A, Sutter E, Côté S, Beerli C, Pognan F, Billich A, Moulin P, Walker UJ.
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| Toxicol Pathol 43(5):694-703. doi: 10.1177/0192623314565650. Epub 2015 Jan 27.
2015
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| 11 | SGPL1
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| Sphingosine-1-phosphate lyase is expressed by CD68+ cells on the parenchymal side of marginal reticular cells in human lymph nodes.
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| Park SM, Angel CE, McIntosh JD, Brooks AE, Middleditch M, Chen CJ, Ruggiero K, Cebon J, Rod Dunbar P.
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| Eur J Immunol 44(8):2425-36. doi: 10.1002/eji.201344158. Epub 2014 Jun 12.
2014
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| 12 | SGPL1, SGPR1
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| Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling.
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| Gatfield J, Monnier L, Studer R, Bolli MH, Steiner B, Nayler O.
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| Cell Signal 26(7):1576-88. doi: 10.1016/j.cellsig.2014.03.029. Epub 2014 Apr 2.
2014
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| 13 | SGPL1
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| Hematopoietic sphingosine 1-phosphate lyase deficiency decreases atherosclerotic lesion development in LDL-receptor deficient mice.
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| Bot M, Van Veldhoven PP, de Jager SC, Johnson J, Nijstad N, Van Santbrink PJ, Westra MM, Van Der Hoeven G, Gijbels MJ, Müller-Tidow C, Varga G, Tietge UJ, Kuiper J, Van Berkel TJ, Nofer JR, Bot I, Biessen EA.
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| PLoS One 8(5):e63360. doi: 10.1371/journal.pone.0063360. Print 2013.
2013
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| 14 | SGPL1
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| Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues.
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| Borowsky AD, Bandhuvula P, Kumar A, Yoshinaga Y, Nefedov M, Fong LG, Zhang M, Baridon B, Dillard L, de Jong P, Young SG, West DB, Saba JD.
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| J Lipid Res 53(9):1920-31. doi: 10.1194/jlr.M028084. Epub 2012 Jul 9.
2012
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| 15 | SGPL1
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| Sphingosine 1-phosphate (S1P) lyase deficiency increases sphingolipid formation via recycling at the expense of de novo biosynthesis in neurons.
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| Hagen-Euteneuer N, Lütjohann D, Park H, Merrill AH Jr, van Echten-Deckert G.
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| J Biol Chem 287(12):9128-36. doi: 10.1074/jbc.M111.302380. Epub 2012 Jan 30.
2012
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| 16 | SGPL1
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| S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism.
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| Kumar A, Oskouian B, Fyrst H, Zhang M, Paris F, Saba JD.
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| Cell Death Dis 2:e119. doi: 10.1038/cddis.2011.3.
2011
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| 17 | SGPL1
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| Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking.
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| Allende ML, Bektas M, Lee BG, Bonifacino E, Kang J, Tuymetova G, Chen W, Saba JD, Proia RL.
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| J Biol Chem 286(9):7348-58. doi: 10.1074/jbc.M110.171819. Epub 2010 Dec 20.
2011
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| 18 | SGPL1
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| Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver.
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| Bektas M, Allende ML, Lee BG, Chen W, Amar MJ, Remaley AT, Saba JD, Proia RL.
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| J Biol Chem 285(14):10880-9. doi: 10.1074/jbc.M109.081489. Epub 2010 Jan 24.
2010
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| 19 | SGPL1
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| Discontinued postnatal thymocyte development in sphingosine 1-phosphate-lyase-deficient mice.
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| Weber C, Krueger A, Münk A, Bode C, Van Veldhoven PP, Gräler MH.
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| J Immunol 183(7):4292-301. doi: 10.4049/jimmunol.0901724. Epub 2009 Sep 11.
2009
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| 20 | SGPL1
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| Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions.
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| Vogel P, Donoviel MS, Read R, Hansen GM, Hazlewood J, Anderson SJ, Sun W, Swaffield J, Oravecz T.
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| PLoS One 4(1):e4112. doi: 10.1371/journal.pone.0004112. Epub 2009 Jan 1.
2009
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| 21 | ACAP1, ARHGAP5, IL36A, LILRA4, PRKAR1B, PSMA2, RHPN2, SGPL1, ZNF432
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| Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry.
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| Zhan X, Desiderio DM.
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| Anal Biochem 354(2):279-89. Epub 2006 Jun 5. 2006
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| 22 | SGPL1
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| Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer.
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| Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD.
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| Proc Natl Acad Sci U S A 103(46):17384-9. Epub 2006 Nov 7.
2006
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| 23 | SGPL1
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| Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1).
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| Van Veldhoven PP, Gijsbers S, Mannaerts GP, Vermeesch JR, Brys V.
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| Biochim Biophys Acta 1487(2-3):128-34. 2000
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| 24 | AARS2, ADAMTSL3, AHRR, AMIGO1, ANKFY1, ARHGAP31, ARID1A, ARID1B, ASAP1, ASB1, BACE1, BIRC6, BRPF3, C14orf118, CASKIN2, CCPG1, CD2BP2, CNOT6, COG6, CPAMD8, DCDC2, DLG3, ERBIN, ERGIC1, FAM190B, FAM63B, FBXO40, FILIP1, FSTL5, FZR1, GALNTL1, GATAD2B, GDA, GMEB2, GNPTAB, GRID1, GRIPAP1, HECTD1, HEG1, HHATL, INTU, IPO9, ISY1, KCNH3, KIAA1143, KIAA1191, KIAA1217, KIAA1274, LCHN, LMBR1L, LRFN2, LRRC47, MACF1, MAP7D1, MIER2, MTA3, MYO5B, MYOF, MYORG, NDFIP2, NDRG2, NELFB, NLGN4X, NLN, OGDHL, PAIP2B, PAK7, PECR, PLEKHG1, PLEKHH1, PNKD, PNMAL2, PPP1R9A, PRDM10, REXO1, RIMKLB, RNF150, SGPL1, SHROOM4, SLC39A10, SLC45A4, SRGAP2, STK36, SULF2, TBC1D24, TLE4, TMCC3, TPCN1, TRMT6, TTC7A, TTC7B, USP31, ZBTB21, ZBTB47, ZC4H2, ZNF490, ZNF644, ZNF777
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| Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.
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| Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O.
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| DNA Res 6(5):329-36. 1999
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| 25 | SGPL1
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| Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast.
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| Zhou J, et al.
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| Biochem Biophys Res Commun 242 : 502-507. 1998
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