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FLASH GENE
Symbol CFLAR contributors: mct - updated : 16-10-2024
HGNC name CASP8 and FADD-like apoptosis regulator
HGNC id 1876
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       gain of function
in inflamed colonic lesions of Crohn's disease
tumoral     --low  
in chemoresistant ovarian cancer cells by siRNA increased apoptosis induced by cisplatin
tumoral     --over  
associated with prostate cancer progression to the androgen-resistant stage
constitutional     --low  
was essential for castration-induced apoptosis in the prostate gland
tumoral        
induces apoptosis in a panel of colorectal cancer cell lines in a manner that is dependent on caspase 8 and TNFRSF10B
tumoral     --over  
in head and neck squamous cell carcinoma
tumoral     --over  
associated with poor prognosis of patients with lung cancer
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerdigestiveliver
biology of CALM1-CFLAR binding may provide new therapeutic targets for cholangiocarcinoma and possibly other cancers
cancerdigestivecolon
targeting CFLAR and BIRC4 may represent a therapeutic strategy for the treatment of colorectal tumors with defects in mitochondrial-regulated apoptosis
cancerurinary 
targeting CFLAR, and especially the c-FLIP(L) isoform, may facilitate apoptosis-based therapies of bladder cancer in otherwise resistant tumours
tumor  
CFLAR downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells
ANIMAL & CELL MODELS
  • mice deficient in Cflar
  • Myeloid specific Flip-deficient mice exhibited growth retardation, premature death, and splenomegaly with altered architecture and extramedullary hematopoiesis