protein
| FADD |
|
CASP8 |
|
CASP3 |
|
TRAF1 |
|
TRAF2 |
|
interacting with FOXO3(target of Akt in endothelial cells that can promote apoptosis via CFLAR down-regulation and activation of the extrinsic apoptotic pathway) |
|
with TNFSF10 |
|
interacting with CALM1 |
|
interaction between MIB1 and CFLAR decreases the association of caspase-8 with CFLAR, which activates caspase-8 and induces cell death |
|
interaction between AKT1 and CFLAR |
|
PML/RARA binds to FAS and blocks FAS-mediated apoptosis in acute promyelocytic leukemia (APL) by forming an apoptotic inhibitory complex with CFLAR |
|
CALM1/CFLAR interaction, with function in regulating Fas-mediated apoptosis and tumorigenesis, which may provide new therapeutic targets for cancer therapy ( |
|
interacting with SART1, a regulator of CFLAR and drug-induced activation of caspase-8 |
|
important role for TRAF7 in the activation of JNK following TNF stimulation and clearly point to an involvement of this protein in regulating the turnover of CFLAR and, consequently, cell death |
|
interaction between CFLAR and the DNA repair protein XRCC6 that regulates CFLAR protein stability by inhibiting its polyubiquitination |
|
TANK, whose expression is increased during osteoclastogenesis, inhibits osteoclast formation, activity and survival, by regulating NFKB1 activity and CFLAR expression |
|
RBM5, a close homologue of RBM10, regulates alternative splicing of apoptosis-related genes, FAS and CFLAR |
|
CASP8/CFLAR heterodimer implicated in control of inflammatory cytokines during microbial infection |
|
CASP8 is required upstream of both CFLAR and CASP10 and death-inducing signaling complex (DISC) formation critically depends on the scaffold function of CASP8 |