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| irs2-/- mice  | |
chico-/-drosophila |
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chronic hyperinsulinemia downregulates the mRNA for IRS2 in ob/ob mice |
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female infertility caused by deletion of IRS2 |
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less Irs2 signaling in aging brains can promote healthy metabolism, attenuate meal-induced oxidative stress, and extend the life span of overweight and insulin-resistant mice |
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Irs2-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function |
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liver content of GCK was reduced in Irs2(-/-) mice as compared with controls, although GCKR levels were similar |
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Irs2 (-/-) mice also exhibited reduced testicular size, suggesting that impairments in this model occur during development |
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complete disruption of Irs2 in mice impairs long-term potentiation (LTP) of synaptic transmission in the hippocampus |