| 1 | IRS2, PLK1
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| Plk1 phosphorylation of IRS2 prevents premature mitotic exit via AKT inactivation.
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| Chen L, Li Z, Ahmad N, Liu X.
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| Biochemistry 54(15):2473-80. doi: 10.1021/acs.biochem.5b00016. Epub 2015 Apr 6.
2015
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| 2 | APPL1, INSR, IRS1, IRS2
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| APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor.
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| Ryu J, Galan AK, Xin X, Dong F, Abdul-Ghani MA, Zhou L, Wang C, Li C, Holmes BM, Sloane LB, Austad SN, Guo S, Musi N, DeFronzo RA, Deng C, White MF, Liu F, Dong LQ.
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| Cell Rep 7(4):1227-38. doi: 10.1016/j.celrep.2014.04.006. Epub 2014 May 10.
2014
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| 3 | DVL2, IRS1, IRS2
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| Insulin receptor substrate 1/2 (IRS1/2) regulates Wnt/β-catenin signaling through blocking autophagic degradation of dishevelled2.
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| Geng Y, Ju Y, Ren F, Qiu Y, Tomita Y, Tomoeda M, Kishida M, Wang Y, Jin L, Su F, Wei C, Jia B, Li Y, Chang Z.
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| J Biol Chem 289(16):11230-41. doi: 10.1074/jbc.M113.544999. Epub 2014 Mar 10.
2014
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| 4 | IRS2
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| Insulin receptor substrate 2 is required for testicular development.
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| Griffeth RJ, Carretero J, Burks DJ.
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| PLoS One 8(5):e62103. doi: 10.1371/journal.pone.0062103. Print 2013.
2013
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| 5 | IRS2
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| Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy.
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| Hookham MB, O'Donovan HC, Church RH, Mercier-Zuber A, Luzi L, Curran SP, Carew RM, Droguett A, Mezzano S, Schubert M, White MF, Crean JK, Brazil DP.
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| FEBS J EBS J. 2013 Apr 25. doi: 10.1111/febs.12305. [Epub ahead of print]
2013
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| 6 | GCK, GCKR, IRS2
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| Insulin-receptor substrate-2 (irs-2) is required for maintaining glucokinase and glucokinase regulatory protein expression in mouse liver.
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| Roncero I, Alvarez E, Acosta C, Sanz C, Barrio P, Hurtado-Carneiro V, Burks D, Blázquez E.
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| PLoS One 8(4):e58797. doi: 10.1371/journal.pone.0058797. Epub 2013 Apr 1.
2013
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| 7 | CAMK4, IRS2
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| The CaMK4/CREB/IRS-2 cascade stimulates proliferation and inhibits apoptosis of β-cells.
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| Liu B, Barbosa-Sampaio H, Jones PM, Persaud SJ, Muller DS.
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| PLoS One 7(9):e45711. doi: 10.1371/journal.pone.0045711. Epub 2012 Sep 25.
2012
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| 8 | IRS2, MAPK8, MAPK9, MAPK9
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| JNK3 maintains expression of the insulin receptor substrate 2 (IRS2) in insulin-secreting cells: functional consequences for insulin signaling.
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| Abdelli S, Bonny C.
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| PLoS One 7(5):e35997. doi: 10.1371/journal.pone.0035997. Epub 2012 May 1.
2012
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| 9 | IRS1, IRS2
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| Association of IRS-1 and IRS-2 genes polymorphisms with polycystic ovary syndrome: a meta-analysis.
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| Ruan Y, Ma J, Xie X.
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| Endocr J 59(7):601-9. Epub 2012 May 21.
2012
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| 10 | IRS2
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| IRS2 signalling is required for the development of a subset of sensory spinal neurons.
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| Chirivella L, Cano-Jaimez M, Pérez-Sánchez F, Herraez L, Carretero J, Fariñas I, Burks DJ, Kirstein M.
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| Eur J Neurosci 35(3):341-52. doi: 10.1111/j.1460-9568.2011.07959.x.
2012
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| 11 | IRS2, PTPN1
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| Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function.
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| Murillo-Cuesta S, Camarero G, González-Rodríguez A, De La Rosa LR, Burks DJ, Avendaño C, Valverde AM, Varela-Nieto I.
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| Mol Med 18:260-9. doi: 10.2119/molmed.2011.00328.
2012
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| 12 | IRS2
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| IRS-2 Deficiency impairs NMDA receptor-dependent long-term potentiation.
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| Martín ED, Sánchez-Perez A, Trejo JL, Martin-Aldana JA, Cano Jaimez M, Pons S, Acosta Umanzor C, Menes L, White MF, Burks DJ.
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| Cereb Cortex 22(8):1717-27. doi: 10.1093/cercor/bhr216. Epub 2011 Sep 27.
2012
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| 13 | IRS2
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| IRS-2 deficiency in macrophages promotes their accumulation in the vascular wall.
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| Mita T, Azuma K, Goto H, Jin WL, Arakawa M, Nomiyama T, Suzuki R, Kubota N, Tobe K, Kadowaki T, Fujitani Y, Hirose T, Kawamori R, Watada H.
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| Biochem Biophys Res Commun 415(4):545-50. doi: 10.1016/j.bbrc.2011.10.086. Epub 2011 Nov 2.
2011
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| 14 | CDH1, FOXO3, IRS2
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| Insulin receptor substrate 2 and FoxO3a signalling are involved in E-cadherin expression and transforming growth factor-β1-induced repression in kidney epithelial cells.
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| Carew RM, Browne MB, Hickey FB, Brazil DP.
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| FEBS J 278(18):3370-80. doi: 10.1111/j.1742-4658.2011.08261.x. Epub 2011 Aug 16.
2011
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| 15 | IRS2
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| Insulin receptor substrate 2 is a negative regulator of memory formation.
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| Irvine EE, Drinkwater L, Radwanska K, Al-Qassab H, Smith MA, O'Brien M, Kielar C, Choudhury AI, Krauss S, Cooper JD, Withers DJ, Giese KP.
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| Learn Mem 18(6):375-83. doi: 10.1101/lm.2111311. Print 2011 Jun.
2011
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| 16 | EIF2AK2, IRS1, IRS2
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| The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells.
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| Yang X, Nath A, Opperman MJ, Chan C.
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| Mol Biol Cell 21(19):3449-58. doi: 10.1091/mbc.E10-06-0481. Epub 2010 Aug 4.
2010
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| 17 | IRS2, ZNF148
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| Neuronal insulin receptor substrate 2 (IRS2) expression is regulated by ZBP89 and SP1 binding to the IRS2 promoter.
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| Udelhoven M, Pasieka M, Leeser U, Krone W, Schubert M.
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| J Endocrinol 204(2):199-208. doi: 10.1677/JOE-09-0266. Epub 2009 Oct 29.
2010
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| 18 | IRS1, IRS2
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| Increased expression of both insulin receptor substrates 1 and 2 confers increased sensitivity to IGF-1 stimulated cell migration.
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| de Blaquière GE, May FE, Westley BR.
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| Endocr Relat Cancer 16(2):635-47. Epub 2009 Mar 4.PMID: 19261680 2009
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| 19 | IRS2, PTPRN, PTPRN2
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| Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth.
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| Torii S, Saito N, Kawano A, Hou N, Ueki K, Kulkarni RN, Takeuchi T.
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| Diabetes 58(3):682-92. doi: 10.2337/db08-0970. Epub 2008 Dec 10.
2009
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| 20 | IRS1, IRS2, IRS4
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| Expression and function of the insulin receptor substrate proteins in cancer.
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| Mardilovich K, Pankratz SL, Shaw LM.
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| J Cell Commun Signal. Jun 17;7:14. doi: 10.1186/1478-811X-7-14 2009
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| 21 | IRS2
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| Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2.
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| Wu J, Tseng YD, Xu CF, Neubert TA, White MF, Hubbard SR.
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| Nat Struct Mol Biol 15(3):251-8. Epub 2008 Feb 17. 2008
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| 22 | IRS2
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| The G1057D polymorphism of IRS-2 gene and its relationship with obesity in conferring susceptibility to type 2 diabetes in Asian Indians.
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| Bodhini D, Radha V, Deepa R, Ghosh S, Majumder PP, Rao MR, Mohan V.
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| Int J Obes (Lond) 31(1):97-102. Epub 2006 Apr 25. 2007
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| 23 | IRS2
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| Brain IRS2 signaling coordinates life span and nutrient homeostasis.
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| Taguchi A, Wartschow LM, White MF.
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| Science 317(5836):369-72. 2007
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| 24 | TFE3, IRS2, HK2, INSIG1
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| TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.
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| Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Furusawa M, Yamamoto T, Inoue N, Matsuzaka T, Takahashi A, Hasty AH, Suzuki H, Sone H, Toyoshima H, Yahagi N, Yamada N.
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| Nat Med 12(1):107-13. Epub 2005 Dec 4. 2006
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| 25 | IRS1, IRS2
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| Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2.
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| Dearth RK, Cui X, Kim HJ, Kuiatse I, Lawrence NA, Zhang X, Divisova J, Britton OL, Mohsin S, Allred DC, Hadsell DL, Lee AV.
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| Mol Cell Biol 26(24):9302-14. Epub 2006 Oct 9. 2006
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| 26 | FOXO1, IRS2
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| The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling.
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| Guo S, Dunn SL, White MF.
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| Mol Endocrinol 20(12):3389-99. Epub 2006 Aug 17.
2006
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| 27 | IRS1, IRS2
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| Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.
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| Ma Z, Gibson SL, Byrne MA, Zhang J, White MF, Shaw LM.
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| Mol Cell Biol 26(24):9338-51. Epub 2006 Oct 9.
2006
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| 28 | IRS1, IRS2, IRS3L, IRS4
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| Differential roles of insulin receptor substrates in brown adipocyte differentiation.
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| Tseng YH, Kriauciunas KM, Kokkotou E, Kahn CR.
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| Mol Cell Biol 24(5):1918-29.PMID: 14966273 2004
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| 29 | IRS2
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| Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation.
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| Lautier C, El Mkadem SA, Renard E, Brun JF, Gris JC, Bringer J, Grigorescu F.
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| Hum Genet 113(1):34-43. Epub 2003 Apr 10. 2003
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| 30 | IRS1, IRS2, IRS4, NISCH
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| Insulin receptor substrate 4 associates with the protein IRAS.
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| Sano H, Liu SC, Lane WS, Piletz JE, Lienhard GE.
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| J Biol Chem 277(22):19439-47. 2002
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| 31 | IRS1, IRS2
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| Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome.
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| Ehrmann DA, Tang X, Yoshiuchi I, Cox NJ, Bell GI.
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| J Clin Endocrinol Metab 87(9):4297-300. 2002
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| 32 | IRS1, IRS2
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| Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms.
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| Le Fur S, Le Stunff C, Bougneres P.
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| Diabetes 51 Suppl 3:S304-7. 2002
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| 33 | IRS2
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| Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice.
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| Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS, Goldstein JL.
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| Mol Cell 6(1):77-86. 2000
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| 34 | IRS2
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| IRS-2 pathways integrate female reproduction and energy homeostasis.
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| Burks DJ, Font de Mora J, Schubert M, Withers DJ, Myers MG, Towery HH, Altamuro SL, Flint CL, White MF.
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| Nature 407(6802):377-82. 2000
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| 35 | IRS2
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| Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.
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| Withers DJ, et al.
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| Nat Genet 23(1):32-40 1999
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| 36 | IRS2
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| Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.
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| Bohni R, Riesgo-Escovar J, Oldham S, Brogiolo W, Stocker H, Andruss BF, Beckingham K, Hafen E.
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| Cell 97(7):865-75. 1999
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| 37 | IRS2
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| Mapping of the human insulin receptor substrate-2 gene, identification of a linked polymorphic marker and linkage analysis in families with Type II diabetes : no evidence for a major susceptibility role.
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| Kalidas K, et al.
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| Diabetologia 41 : 1389-1391. 1998
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| 38 | IRS2
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| Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes.
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| Rother KI, Imai Y, Caruso M, Beguinot F, Formisano P, Accili D.
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| J Biol Chem 273(28):17491-7. 1998
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| 39 | IRS2, IRS4
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| The IRS-signalling system: a network of docking proteins that mediate insulin action.
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| White MF.
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| Mol Cell Biochem 182(1-2):3-11. Review. 1998
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| 40 | IRS2
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| Disruption of IRS-2 causes type 2 diabetes in mice.
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| Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF.
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| Nature 391(6670):900-4. 1998
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| 41 | IRS2
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| 14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain.
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| Ogihara T, Isobe T, Ichimura T, Taoka M, Funaki M, Sakoda H, Onishi Y, Inukai K, Anai M, Fukushima Y, Kikuchi M, Yazaki Y, Oka Y, Asano T.
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| J Biol Chem 272(40):25267-74. 1997
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| 42 | IRS2
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| Role of IRS-2 in insulin and cytokine signalling.
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| Sun XJ, Wang LM, Zhang Y, Yenush L, Myers MG Jr, Glasheen E, Lane WS, Pierce JH, White MF.
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| Nature 377(6545):173-7. 1995
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