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FLASH GENE

Symbol

IRS2

contributors: mct/npt/pgu - updated : 12-06-2015

HGNC name	insulin receptor substrate 2
HGNC id	6126

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

NIDDM3

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in macrophages enhanced their accumulation in the vascular wall accompanied by increased expression of proinflammatory mediators in macrophages constitutional     --over   in the kidney tubules of diabetic nephropathy constitutional     --low   in Type 2 diabetics as well as in Alzheimer patients (

Susceptibility

polycystic ovary syndrome in non diabetic African-American women with th G/G genotype (G1057D) polymorphism morbid obesity with glucose intolerance

Variant & Polymorphism

Candidate gene
Marker	marker and/or mediator of diabetic nephropathy progression
Therapy target
	System Type Disorder Pubmed cancer     new models to develop inhibitors against IRSs for anticancer therapy neurology neurodegenerative huntington chorea decreasing IRS2 signaling could be part of a therapeutic approach to slow the progression of HD diabete metabolic syndrom   reduced IRS2-mediated insulin signal in macrophages is a potentially important therapeutic target to prevent the progression of atherosclerosis in patients with type 2 diabetes

ANIMAL & CELL MODELS

	irs2-/- mice
	chico-/-drosophila
	chronic hyperinsulinemia downregulates the mRNA for IRS2 in ob/ob mice
	female infertility caused by deletion of IRS2
	less Irs2 signaling in aging brains can promote healthy metabolism, attenuate meal-induced oxidative stress, and extend the life span of overweight and insulin-resistant mice
	Irs2-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function
	liver content of GCK was reduced in Irs2(-/-) mice as compared with controls, although GCKR levels were similar
	Irs2 (-/-) mice also exhibited reduced testicular size, suggesting that impairments in this model occur during development
	complete disruption of Irs2 in mice impairs long-term potentiation (LTP) of synaptic transmission in the hippocampus