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FLASH GENE

Symbol

NOS1

contributors: mct/npt - updated : 04-02-2019

HGNC name	nitric oxide synthase 1 (neuronal)
HGNC id	7872

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in glial tumors, which was significantly correlated with histologic grade and proliferative potential(Tanriover 2008) constitutional     --over   in the intervertebral disk degeneration constitutional     --low   in muscle aging, loss of NOS1, the primary source of muscle NO

Susceptibility

to infantile pyloric stenosis and to asthma to enuresis

Variant & Polymorphism SNP	SNP in the exon 1C 84G/A increases the risk of infantile pyloric stenosis
	predominantly CC genotype may be associated with enuresis

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous senescence   expression of a muscle-specific NOS1 transgene restores calpain S-nitrosylation in aging muscle and prevents sarcopenia miscelleaneous pain   blocking NOS1 signaling in the periphery may thus be a novel therapeutic strategy for the treatment of neuropathic pain

ANIMAL & CELL MODELS