protein
| linking integrin subunits to FYN |
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negative regulator of RAS |
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DYSF (functional role for caveolins in a novel post-Golgi trafficking pathway followed by dysferlin) |
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substrate of PTPN1 |
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caveolin-2, CAV2 |
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amyloid precursor protein, APP |
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G-protein coupled receptor kinase 2, GRK2 |
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flotillins 1 and 2 ( |
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Phospholipase D2, PLD2 |
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protein kinase A, PKA |
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androgen receptor, AR |
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mal, T-cell differentiation protein-like, MALL |
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Bruton's tyrosine kinase, BTK and BMX non-receptor tyrosine kinase, Bmx |
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tumor necrosis factor-alpha receptor-associated factor 2 TRAF2 and C-terminal Src kinase, Csk |
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PTP1B, PTP1C, SHPTP2, PTEN, and LAR |
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serine/threonine protein phosphatases PP1 and PP2A |
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CD147 ( |
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integrin linked kinase 1, ILK1 |
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SCP2 (bound caveolin-1 through a new domain identified in the N-terminal domain of caveolin-1 between aa 34-40) |
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FLNA, a novel CAV1-dependent target in IGF1-stimulated cancer cell migration |
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CAV1 interacts with TRPC1 and ITPR3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells |
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interaction between IFITM1 and CAV1 could enhance the inhibitory effect of CAV1 on ERK activation) |
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CAV1 regulates hyperoxia/ROS-induced apoptosis through interactions with FAS and BID, probably via FAS palmitoylation and CAV1 Y14 phosphorylation, respectively |
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role of PTRF in cellular senescence is dependent on its targeting to caveolae and its interaction with CAV1, which appeared to be regulated by the phosphorylation of PTRF |
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cooperative roles of C-terminal Src kinase (CSK) binding protein (PAG1) and Caveolin-1 (CAV1) in the mechanism of Src family tyrosine kinase (SFK) inhibition by CSK |
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DSG2 associates with CAV1, the major protein of specialized membrane microdomains called caveolae, which functions in both membrane protein turnover and intracellular signaling |
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region of DLC1 required for interaction with CAV1 to the DLC1 is the START domain |
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KRASK-RAS regulates both caveolin-1 expression and other factors affecting caveolin-1 functions in colon cancer-derived cell migration |
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is positively regulated at the transcriptional level through a novel calcium signaling pathway mediated by NFATC1 |
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is a novel physiological activator of PPP5C |
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may be a cofactor in the interaction of DERL1 and PTGS2 and may facilitate DERL1- and VCP complex-mediated PTGS2 ubiquitination, retrotranslocation, and degradation |
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plays a critical role for the development of abdominal aortic aneurysm at least in part via its specific alteration of AGT signalling within caveolae |
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CAV1 interacts with ABCG1 and regulates ABCG1-mediated cholesterol efflux |
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regulate ABCA1 and ABCG1-mediated cholesterol efflux probably via interacting with them |
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in hepatocytes, is required for TGFB1-mediated activation of the metalloprotease ADAM17 that is responsible for shedding of EGFR ligands and activation of the EGFR pathway, which counteracts the TGFB1 pro-apoptotic effects |
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regulates P2RX7 signaling in osteoblasts |
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PLAA is located in caveolae, where it interacts with PDIA3 and CAV1 to initiate rapid signaling via CAMK2A, CAMK2B |
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PRKCDBP is targeted to caveolae by PTRF where it interacts with the scaffolding domain of CAV11 and promote caveolae dynamics |
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coupling between ESR1 and lipid raft CAV1 is critical for membrane ER signaling in synaptic plasticity and therefore, increased coupling of CAV1 and ESR1 may elucidate a critical abnormal mechanism of Fragile X syndrome (FRAXA) |
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protein-protein interaction between CAV1 and PTPN11 is dependent on the N-SH2 domain of PTPN11 |
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insulin stimulation of its own uptake requires CAV1 phosphorylation and Src-kinase activity |
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PTRF actively cooperating with CAV1 in the morphogenesis of caveolae, and interaction between PTRF and CAV1 underlies the cell growth and migration in myogenic tumors |
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CAV1-positive early endosomes may act as a multifunctional device for TGFB1 signaling and TGFB1 receptor recycling and degradation |
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correlations of MYOCD with CAV1 in a majority of human tissues and in the heart, correlation with MKL2 |
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CAV1 is a powerful negative regulator of the excitatory glutamate transporters SLC1A1, SLC1A2, SLC1A3, SLC1A6 |
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SEPTIN11 associated with caveolae in mature adipocytes and interacted with both CAV1 and the intracellular fatty acid chaperone, fatty acid binding protein 5 (FABP5) |
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E3 ubiquitin ligase ZNRF1 modulates CAV1 protein stability to regulate Toll-like receptor (TLR) 4-triggered immune responses |
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CAV1, a key component of caveolae, interacted with WASHC5 in cells, and WASHC5 inhibited the lysosomal degradation of CAV1 |