| basic FUNCTION
| non selective cation channel enabling Ca2+ influx into cells |
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supposed to have a fundamental role in the regulation of smooth muscle tone in blood vessels and lung ( |
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may influence sperm motility |
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calcium (Ca2+) and magnesium (Mg2+) conducting channel, during proliferation of human osteoblasts |
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its activation is sufficient to induce keratinocyte differentiation similar to the physiological stimulus [Ca2+] |
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playing an essential role for proper regulation of podocyte structure and function, by its channel activity at the slit diaphragm |
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Ca2+-permeable channel, activation of which is linked to a G protein-coupled receptor or receptor tyrosine kinase signaling pathway |
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playing a unique and indispensable role in acute hypoxic pulmonary vasoconstriction |
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required for BDNF-mediated neuronal protection and protects cerebellar granule neurons against serum deprivation |
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might act as an important mediator for sensing the extracellular signals that affect synaptic and behavioral plasticity |
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involvement of TRPC6-mediated Ca2+ entry in the RHOA-dependent regulation of actin cytoskeleton has been demonstrated in endothelial cells and kidney podocytes |
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playing an essential role for angiotensin II-induced cardiac hypertrophy |
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contributes to the Ca(2+) leak of human erythrocytes |
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promotes hippocampal neuron dendritic growth |
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regulates TRPC3 activation by erythropoietin by modulation of signaling mechanisms, including reduced interaction of TRPC6 with phospholipase C gamma and Epo-R |
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may be involved in VEGF-mediated angiogenesis |
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participates both in cacapitative Ca2+ entry and non capacitative Ca2+ entry through its interaction with the Orai-STIM1 complex or TRPC3 respectively |
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invovled in the development of gastric cancers through the regulation of Ca2+ elevation which is essential for G2/M transition |
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necessary mediator of pathologic cardiac hypertrophy, in part through a calcineurin/NFAT signaling pathway |
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TRPC5 and TRPC6 are antagonistic regulators of actin remodeling and cell motility in fibroblasts and kidney podocytes |
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TRPC5 and TRPC6 channels are now known as the Ca(2+) influx pathways for nonselective, cationic current in podocytes |
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upregulation of TRPC6 is involved in the Ca2+ signaling and actin assembly in human mesangial cells (MCs) after chronic hypoxia |
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role of TRPC6 in actin assembly and reorganization in response to chronic hypoxia |
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TRPC3 and TRPC6 are thus required for the normal function of cells involved in touch and hearing, and are potential components of mechanotransducing complexes |
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dual and context dependent role of TRPC6 in podocytes where acute activation protects from complement-mediated damage, but chronic overactivation leads to focal segmental glomerulosclerosis |
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is the endothelial calcium channel that regulates leukocyte transendothelial migration during the inflammatory response |
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TRPC6 channel translocation into phagosomal membrane augments phagosomal function |
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may protect renal ischemia-reperfusion injury through inhibiting necroptosis of renal tubular epithelial cells |
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is emerging as a functional element for the control of calcium currents in immune-committed cells and target tissues |
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is important in glomerular epithelial cells or podocytes for the process of glomerular filtration |
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TRPC6 plays a crucial role in the development of kidney injuries by inducing podocyte injury, maybe via its role in the immune system |
