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FLASH GENE

Symbol

SPAG1

contributors: mct/npt - updated : 23-11-2013

HGNC name	sperm associated antigen 1
HGNC id	11212

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	nine TPR domains
	nine tetratricopeptide repeat motifs (TPRs) that form scaffolds to mediate protein-protein interactions and are often involved in the assembly of multiprotein complexes
	an ATP/GTP-binding site
	multiple putative phosphorylation sites (Neesse 2007)

HOMOLOGY

interspecies	homolog to murine Spag1
	ortholog to D. rerio spag1

Homologene

FAMILY

CATEGORY

regulatory , antigen

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule
text	membrane of the germ cells
	colocalization of SPAG1 with microtubules

basic FUNCTION	regulating GTP signal transduction pathway involved inspermatogenesis and fertilization
	could contribute to the early spread and poor prognosis of pancreatic adenocarcinoma
	potential role of SPAG1 in cancer cell motility
	probably plays a role in the cytoplasmic assembly and/or trafficking of the axonemal dynein arms
	probably not an integral axonemal protein but plays a role in the cytoplasmic assembly of the ciliary dynein arms

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ICS29

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in a large proportion of pancreatic ductal adenocarcinomas (PDAC)

Susceptibility

Variant & Polymorphism

Candidate gene	marker of PDAC progression
Marker
Therapy target

ANIMAL & CELL MODELS