Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SPAG1 contributors: mct/npt - updated : 23-11-2013
HGNC name sperm associated antigen 1
HGNC id 11212
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly Homo sapiens
Nervousbrain   highly Homo sapiens
Reproductivemale systemtestis  predominantly Homo sapiens
Respiratorylung     Homo sapiens
Urinarykidney   highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivesperm cell
Reproductivespermatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nine TPR domains
  • nine tetratricopeptide repeat motifs (TPRs) that form scaffolds to mediate protein-protein interactions and are often involved in the assembly of multiprotein complexes
  • an ATP/GTP-binding site
  • multiple putative phosphorylation sites (Neesse 2007)
  • HOMOLOGY
    interspecies homolog to murine Spag1
    ortholog to D. rerio spag1
    Homologene
    FAMILY
    CATEGORY regulatory , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • membrane of the germ cells
  • colocalization of SPAG1 with microtubules
  • basic FUNCTION
  • regulating GTP signal transduction pathway involved inspermatogenesis and fertilization
  • could contribute to the early spread and poor prognosis of pancreatic adenocarcinoma
  • potential role of SPAG1 in cancer cell motility
  • probably plays a role in the cytoplasmic assembly and/or trafficking of the axonemal dynein arms
  • probably not an integral axonemal protein but plays a role in the cytoplasmic assembly of the ciliary dynein arms
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ICS29
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in a large proportion of pancreatic ductal adenocarcinomas (PDAC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene marker of PDAC progression
    Marker
    Therapy target
    ANIMAL & CELL MODELS