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FLASH GENE
Symbol GPAA1 contributors: mct - updated : 11-09-2019
HGNC name glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)
HGNC id 4446
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cytoplasmic N terminus and a large luminal loop between its first two transmembrane spans
  • a siggnal peptide
  • a GPI transamidase, component domain
  • two phosphorylation sites
  • two N-glysocylation sites
  • a leucine zipper motif
  • eight transmembrane segments (TM8)
    • HOMOLOGY
    interspecies homolog to yeast Gaa1p
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • likely is passively retained in the ER by a signalless mechanism
    • basic FUNCTION
  • glycosylphosphatidylinositol anchor attachment protein 1
  • is predicted to be the enzyme that catalyzes the attachment of the glycosylphosphatidyl (GPI) lipid anchor to the carbonyl intermediate of the substrate protein at the omega-site
  • is the subunit of the GPI transamidase that transfers the GPI anchor to proteins within the ER
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component putative component of GPItransamidase (see PIGK)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PIGT, PIGU, and GPAA1 may form a core complex associated by PIGS, and these four subunits may stabilize PIGK, triggering GPI anchoring reactions
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GPIBD15
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in gastric cancer
    tumoral     --over  
    in patients with colorectal cancer, which indicates that it might play an important role in the proliferation, invasion, and metastasis of colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • GPAA1 could be a promising diagnostic biomarker for gastric cancer
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    therapeutic target for gastric cancer
    ANIMAL & CELL MODELS