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FLASH GENE

Symbol

GPAA1

contributors: mct - updated : 11-09-2019

HGNC name	glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)
HGNC id	4446

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003801 12 - 2058 NP_003792 67.5 621 - 2017 29100095

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid         Homo sapiens Urinary kidney         Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a cytoplasmic N terminus and a large luminal loop between its first two transmembrane spans
	a siggnal peptide
	a GPI transamidase, component domain
	two phosphorylation sites
	two N-glysocylation sites
	a leucine zipper motif
	eight transmembrane segments (TM8)

HOMOLOGY

interspecies

homolog to yeast Gaa1p

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	likely is passively retained in the ER by a signalless mechanism

basic FUNCTION	glycosylphosphatidylinositol anchor attachment protein 1
	is predicted to be the enzyme that catalyzes the attachment of the glycosylphosphatidyl (GPI) lipid anchor to the carbonyl intermediate of the substrate protein at the omega-site
	is the subunit of the GPI transamidase that transfers the GPI anchor to proteins within the ER

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

putative component of GPItransamidase (see PIGK)

INTERACTION

DNA

RNA

small molecule

protein

PIGT, PIGU, and GPAA1 may form a core complex associated by PIGS, and these four subunits may stabilize PIGK, triggering GPI anchoring reactions

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

GPIBD15

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function in gastric cancer tumoral     --over   in patients with colorectal cancer, which indicates that it might play an important role in the proliferation, invasion, and metastasis of colorectal cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	GPAA1 could be a promising diagnostic biomarker for gastric cancer
Therapy target
	System Type Disorder Pubmed cancer digestive stomach therapeutic target for gastric cancer

ANIMAL & CELL MODELS