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FLASH GENE
Symbol PSMG1 contributors: mct - updated : 06-11-2024
HGNC name proteasome (prosome, macropain) assembly chaperone 1
HGNC id 3043
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • leucine rich protein
  • two transmembrane helices (2TM)
    • mono polymer heteromer , dimer
    isoforms Precursor 43 kDa precursor protein, from which the N-terminus is cleaved resulting in a polypeptide of 41 kDa
    HOMOLOGY
    interspecies ortholog to murine Dscr2
    ortholog to rattus Dscr2_predicted
    homolog to chicken DSCR2
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • maintained on the cytoplasmic side of the ER by indirect interaction with the ER membrane or with another protein
  • targeted to a cytoplasmic compartment as a soluble form
    • basic FUNCTION
  • involved in the maturation of the 20S proteasomes
  • is a proteaseome assembly chaperone that dimerizes with PSMG2, to form the PSMG1/PSMG2 complex
  • PSMG1 and PSMG4 might be involved in various cancers, including acute myeloid leukemia (AML)
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer PSMG1 and PSMG2
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other degraded after formation of the 20S proteasome is completed
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to Crohn disease
  • to Takayasu arteritis
    • Variant & Polymorphism other
  • rs2836878 associated to Crohn disease
    • Candidate gene
    Marker for survival in acute myeloid leukemia
    Therapy target
    ANIMAL & CELL MODELS