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FLASH GENE
Symbol PSMG1 contributors: npt - updated : 24-05-2006
HGNC name proteasome (prosome, macropain) assembly chaperone 1
HGNC id 3043
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1146 32 288 - -
- splicing 1083 30 267 - Sommer (unpublished)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveliver   moderately
 stomach   moderately
Reproductivefemale systemuteruscervix predominantly
 male systemtestis  highly
Urinarykidney   highly
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Muscular    
Nervousperipherous   
cell lineage
cell lines leukemic T cell line, Jurkat and others
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text all tissues
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • leucine rich protein
  • two transmembrane helices (2TM)
  • mono polymer heteromer , dimer
    isoforms Precursor 43 kDa precursor protein, from which the N-terminus is cleaved resulting in a polypeptide of 41 kDa
    HOMOLOGY
    interspecies ortholog to murine Dscr2
    ortholog to rattus Dscr2_predicted
    homolog to chicken DSCR2
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    text
  • maintained on the cytoplasmic side of the ER by indirect interaction with the ER membrane or with another protein
  • targeted to a cytoplasmic compartment as a soluble form
  • basic FUNCTION
  • involved in the maturation of the 20S proteasomes
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer PSMG1 and PSMG2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other degraded after formation of the 20S proteasome is completed
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS