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FLASH GENE

Symbol

PSMG1

contributors: mct - updated : 06-11-2024

HGNC name	proteasome (prosome, macropain) assembly chaperone 1
HGNC id	3043

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	8.75 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003720 7 - 1754 NP_003711 32 288 - 2004 15590417 NM_203433 6 splicing 1077 NP_982257 30 267 - 2004 15590417 NM_001261824 7 - 1124 NP_001248753 - 283 - 2004 15590417 NM_001320795 7 - 1332 NP_001307724 - 201 - 2004 15590417

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive liver       moderately   stomach       moderately Reproductive female system uterus cervix   predominantly   male system testis     highly Urinary kidney       highly Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Muscular         Nervous peripherous

cell lineage
cell lines	leukemic T cell line, Jurkat and others
fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	all tissues

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	leucine rich protein
	two transmembrane helices (2TM)

mono polymer

heteromer , dimer

isoforms

Precursor

43 kDa precursor protein, from which the N-terminus is cleaved resulting in a polypeptide of 41 kDa

HOMOLOGY

interspecies	ortholog to murine Dscr2
	ortholog to rattus Dscr2_predicted
	homolog to chicken DSCR2

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm
text	maintained on the cytoplasmic side of the ER by indirect interaction with the ER membrane or with another protein
	targeted to a cytoplasmic compartment as a soluble form

basic FUNCTION	involved in the maturation of the 20S proteasomes
	is a proteaseome assembly chaperone that dimerizes with PSMG2, to form the PSMG1/PSMG2 complex
	PSMG1 and PSMG4 might be involved in various cancers, including acute myeloid leukemia (AML)

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heterodimer PSMG1 and PSMG2

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

degraded after formation of the 20S proteasome is completed

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to Crohn disease to Takayasu arteritis

Variant & Polymorphism other	rs2836878 associated to Crohn disease

Candidate gene
Marker	for survival in acute myeloid leukemia
Therapy target

ANIMAL & CELL MODELS