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FLASH GENE

Symbol

GJB5

contributors: npt/ - updated : 02-05-2006

HGNC name	gap junction protein, beta 5, 31.1kDa
HGNC id	4287

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Nervous brain         Reproductive male system prostate       Respiratory lung         Skin/Tegument skin

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Epithelial barrier/lining       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four hydrophobic transmembrane segments separating the N terminal intracellular domain
	two extracellular loops
	a C terminal intracellular domain

HOMOLOGY

interspecies	ortholog to murine Gjb5
	homolog to C.elegans E02C12.3

Homologene

FAMILY	connexin family
	beta-type (group I) subfamily

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION

basic FUNCTION

having a role in intercellular transport and communication

CELLULAR PROCESS	cell life, differentiation
	cell communication

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	epidermal differentiation

PATHWAY

metabolism

signaling

a component

monomer constituent of the connexon (six subunits)

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS