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FLASH GENE
Symbol GJB5 contributors: npt/ - updated : 02-05-2006
HGNC name gap junction protein, beta 5, 31.1kDa
HGNC id 4287
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Epithelialbarrier/lining   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four hydrophobic transmembrane segments separating the N terminal intracellular domain
  • two extracellular loops
  • a C terminal intracellular domain
  • HOMOLOGY
    interspecies ortholog to murine Gjb5
    homolog to C.elegans E02C12.3
    Homologene
    FAMILY
  • connexin family
  • beta-type (group I) subfamily
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • having a role in intercellular transport and communication
  • CELLULAR PROCESS cell life, differentiation
    cell communication
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text epidermal differentiation
    PATHWAY
    metabolism
    signaling
    a component
  • monomer constituent of the connexon (six subunits)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS