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FLASH GENE

Symbol

TNFRSF25

contributors: mct/pgu - updated : 04-12-2012

HGNC name	tumor necrosis factor receptor superfamily, member 25
HGNC id	11910

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in neuroblastoma cell lines tumoral     --over   in primitive neuroectodermal tumors with good prognosis

Susceptibility

to rheumatoid arthritis increased in term placentas from women with pregnancies complicated by preeclampsia up-regulated in renal tubular epithelial cells and endothelial cells of some interlobular arteries during acute transplant rejection

Variant & Polymorphism other	D158G mutation increasing the risk of rheumatoid arthritis

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed blood coagulation   proatherogenic role for both TNFSF15 and TNFRSF25 that implicates this pathway as a target for the therapeutic intervention of atherosclerosis

ANIMAL & CELL MODELS