Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TNFRSF25 contributors: mct/pgu - updated : 04-12-2012
HGNC name tumor necrosis factor receptor superfamily, member 25
HGNC id 11910
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four extracytoplasmic cysteine-rich pseudorepeats typical for TNFR superfamily
  • a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
  • a cytoplasmic tail with the DEATH domain
  • an extracellular domain with four homologous cysteine-rich domains (CRDs)
    • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • tumor necrosis factor receptor superfamily
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION
    text several secreted isoforms
    basic FUNCTION
  • inducing NFKB acitivation and apoptosis when overexpressed
  • involved in the regulation of apoptosis in neuroblastoma and primitive neuroectodermal tumors
  • may play a role in lymphocyte homeostasis
  • may be involved in the removal of self-reactive T cells in the thymus
  • has an essential role in the development of allergic lung inflammation
  • potential inducible mediator of tubular inflammation and injury
  • involved in atherosclerosis via the induction of proinflammatory cytokines/chemokines and decreasing plaque stability by inducing extracellular matrix degrading enzymes
  • can mediate apoptosis in osteoblasts
  • TNFSF15 and TNFRSF25 may play an important role in the pathophysiological process of the aged bladder
    • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with BAG4
  • interacts strongly via the death domains of TNFRSF1
  • TNFSF15-TNFRSF25 interactions are necessary and sufficient for T cell-dependent inflammatory bowel disease
  • TRADD is essential for TNFSF15/TNFRSF25 signaling
  • costimulates T-cell activation, but it is unique among these receptors in that it signals through an intracytoplasmic death domain and the adapter protein TRADD (TNFR-associated death domain)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in neuroblastoma cell lines
    tumoral     --over  
    in primitive neuroectodermal tumors with good prognosis
    Susceptibility
  • to rheumatoid arthritis
  • increased in term placentas from women with pregnancies complicated by preeclampsia
  • up-regulated in renal tubular epithelial cells and endothelial cells of some interlobular arteries during acute transplant rejection
    • Variant & Polymorphism other D158G mutation increasing the risk of rheumatoid arthritis
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    bloodcoagulation 
    proatherogenic role for both TNFSF15 and TNFRSF25 that implicates this pathway as a target for the therapeutic intervention of atherosclerosis
    ANIMAL & CELL MODELS