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FLASH GENE

Symbol

TNFRSF10A

contributors: mct - updated : 07-01-2015

HGNC name	tumor necrosis factor receptor superfamily, member 10a
HGNC id	11904

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in nasopharyngeal cancer

Susceptibility

to cancer

Variant & Polymorphism SNP	A683C with tumor specific allele distribution
	A1322G G allele and A683C C allele are associated with increased risk for cancer

Candidate gene
Marker
Therapy target	cytotoxic agents capable of up-regulating the expression of TNFRSF10A and TNFRSF10B can sensitize cancer cells to TNFSF10 induced apoptosis

ANIMAL & CELL MODELS